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Myasthenia Gravis

Disease Mechanism and Immunointervention

Editors: Christadoss, Premkumar (Ed.)

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About this book

Autoimmune myasthenia gravis (MG) is a classical autoimmune disease, for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue, and weakness.
In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model, experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune response to the acetylcholine receptor (AChR). These advances are leading to the development of specific methods of immunointervention in EAMG. Further understanding of the intricate involvement of the major histocompatibility complex (MHC) and non-MHC genes, T cell receptors (TCR), costimulator molecules, and specific cytokines in the afferent and efferent autoimmune response of AChR should pave the way to future antigen/clone-specific therapy of MG.
This book is the outcome of the MG workshop proceedings in Mysore, India, 1998. The majority of the chapters in this book are contributed by world-renowned authors and their students. The book not only contains a timely review of specific topics, but also up-to-date findings. Immunologists and neurologists will find, in this volume, the latest in MG/EAMG cutting-edge research. Clinicians will be interested in the applications of the various immunointervention strategies into clinical trials in MG patients. Finally, students will not only be interested in reading the latest in EAMG/MG research, but will also find information to help them develop a future strategy to unravel the precise mechanism of disease.
To summarize, in this book, the readers should find up-to-date information related to immunological mechanisms involved in MG pathogenesis and various modalities for possible approaches to immunointervention to treat MG.

Table of contents (18 chapters)

Table of contents (18 chapters)
  • Current Concepts on the Structure of Acetylcholine Receptor with Relevance to Myasthenia Gravis and Experimental Autoimmune Myasthenia Gravis Pathogenesis

    Pages 1-19

    Tzartos, Socrates

  • Tolerance of a Transgenic Self Antigen Expressed in the Thymus: Implication for Myasthenia gravis

    Pages 20-27

    Salmon, Anne-Marie (et al.)

  • Low Levels of Acetylcholine Receptor Delta-Subunit Message and Protein in Human Thymus Suggests the Occurrence of ‘Triplet Receptors’ in Thymic Myoid Cells

    Pages 28-34

    Marx, Alexander (et al.)

  • Aberrant Encounter of Acetylcholine Receptor-Expressing Cells with the Lymphoid Infiltrates in the Thymus of Myasthenia Gravis Patients

    Pages 35-41

    Roxanis, Ioannis (et al.)

  • Expression of the Acetylcholine Receptor α-Subunit Gene is Associated with Paraneoplastic Myasthenia Gravis in Mixed Thymoma

    Pages 42-50

    Gutsche, Stefanie (et al.)

Buy this book

eBook $89.00
price for USA in USD
  • ISBN 978-94-011-4060-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-0-7923-6278-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $119.99
price for USA in USD
  • ISBN 978-94-010-5787-5
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Myasthenia Gravis
Book Subtitle
Disease Mechanism and Immunointervention
Editors
  • Premkumar Christadoss
Copyright
2000
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
Distribution Rights
No sales rights in Pakistan, Bangladesh, Nepal, Sri Lanka, Middle East and Africa
eBook ISBN
978-94-011-4060-7
DOI
10.1007/978-94-011-4060-7
Hardcover ISBN
978-0-7923-6278-4
Softcover ISBN
978-94-010-5787-5
Edition Number
1
Number of Pages
XIII, 208
Topics

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