Developments in Hematology and Immunology

Cytokines and Growth Factors in Blood Transfusion

Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord Nederland

Editors: Smit Sibinga, Cees, Das, P.C., Löwenberg, B. (Eds.)

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About this book

Cytokines are cellular growth factors which also provide communication between cells and their milieu. This clearly is an exciting area in modern medicine that will have significant impact on various facets of transfusion. Erythropoietin therapy stimulates red cell production while thrombopoietin seems to positively affect megakaryopoiesis and can be an added armamentarium for the thrombocytopenic patient.
Using haematnopoietic growth factors, stem cells could be mobilized early to the peripheral blood for collection and subsequent transplantation into haemato-oncology patients instead of bone marrow transplantation. Using a cocktail of cytokines in cell culture, stem cells could be expanded and selected for therapy. Cytokines and growth factors can even be modified, which may lead to successful gene therapy in malignancies, including solid tumour vaccines. However, the presence of cytokines in certain blood products could have biological effects following transfusion, although its clinical relevance needs to be ascertained. There is much potential for the use of cytokines in the treatment of infections. Early diagnostic methods are now available to monitor their levels and relevance. It is likely that cytokines will increasingly play a role in therapy and could develop our fundamental knowledge about the development of T-cells. An ethical dilemma remains, however, regarding the use of cytokines in healthy donors for harvesting suitable specific cells. Longer clinical observation will be necessary to gather the necessary information.
Cytokines and growth factors in blood transfusion was the theme of the 21st International Symposium in Blood Transfusion, where twenty clinicians and scientists, experts in their own fields, were invited to update the above information. Their findings are presented in four sections in this volume:

  • Fundamental aspects - cytokines in development of T-cells, growth factors in haematopoiesis, growth factor receptors and signal transduction, cytokine response in platelet and whole blood transfusions.
  • Function, production and diagnosis &endash; laboratory diagnostics of cytokines and growth factors, cytokines in blood components, cytokines and growth factors in cell expansions, cytokines for genetic modification towards gene therapy, progenitor cells from healthy donors.
  • Application in clinical medicine &endash; clinical relevance of cytokines in transfusion products, cytokines and growth factors in solid tumours, gene therapy in malignancies, vaccine strategies inducing T-cell immunity against tumours, cytokines in the treatment of infections, thrombopoietin and megakaryopoiesis.
  • Future potential use in transfusion medicine &endash; erythropoietin, immunotherapy, ethical aspects of the use of cytokines and growth factors in donors, potential of cytokines and growth factors in transfusion medicine.

Reviews

`Well referenced throughout, this monograph then is a unique collection of the current research and discussion on this important topic. Of particular value to transfusion specialist clinicians and medical scientists, this monograph would also be of interest to haematology specialists and scientists, and researchers in these fields.'
Australian Journal of Medical Science, 20:3 (1999)

Table of contents (19 chapters)

Table of contents (19 chapters)
  • The Role of the Common Gamma Chain of the IL-2, IL-4, IL-7 and IL-15 Receptors in Development of Lymphocytes. Constitutive Expression of Bcl-2 does not Rescue the Developmental Defects in Gamma Common-Deficient Mice

    Pages 3-11

    Blom, B. (et al.)

  • Molecular Mechanisms Involved in the Control of Differential Cytokine Expression in Human Monocytes

    Pages 13-18

    Tuyt, L. M. L. (et al.)

  • Signal Transduction from the Haematopoietic Growth Factor Receptors

    Pages 19-27

    Touw, I. P.

  • Recipient Immune Responses Induced by Allogeneic Whole Blood or Platelet Transfusions: Implications for Immunomodulation

    Pages 29-38

    Semple, J. W. (et al.)

  • Use and Application of Cytokines and Growth Factors in Laboratory Diagnostic Procedures

    Pages 49-62

    Fujihara, M. (et al.)

Buy this book

eBook $129.00
price for USA in USD
  • ISBN 978-1-4613-1137-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-7923-4787-3
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $169.99
price for USA in USD
  • ISBN 978-1-4612-8435-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Cytokines and Growth Factors in Blood Transfusion
Book Subtitle
Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord Nederland
Editors
  • Cees Smit Sibinga
  • P.C. Das
  • B. Löwenberg
Series Title
Developments in Hematology and Immunology
Series Volume
32
Copyright
1997
Publisher
Springer US
Copyright Holder
Kluwer Academic Publishers
eBook ISBN
978-1-4613-1137-9
DOI
10.1007/978-1-4613-1137-9
Hardcover ISBN
978-0-7923-4787-3
Softcover ISBN
978-1-4612-8435-2
Edition Number
1
Number of Pages
XIV, 206
Topics