Brain Tumor Invasiveness

Editors: Goldfarb, Ronald H. (Ed.)

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About this book

It is widely appreciated that the pathophysiology of advanced brain cancer is intimately related to the extent of tumor invasiveness. A prerequisite for comprehensively understanding neuro-oncology is therefore the elucidation of the biochemical and molecular properties of tumor cells that contribute to their invasiveness. An understanding of tumor invasion for central nervous system tumors is crucial since malignant brain tumors are very highly invasive and extensively destroy adjacent neural brain tissue. Moreover, they are angiogenesis-dependent and lead to the death of patients by expanding within the limited space of the cranium. As more specific insights are gained towards a full understanding of the complex process of tumor invasiveness of brain tumor cells, it should be possible to design strategies for the early diagnosis and treatment of invasive, advanced brain tumors. There is therefore an urgent need to better understand the cellular properties of brain tumor cells responsible for invasiveness.
This special issue of the JOURNAL OF NEURO-ONCOLOGY provides a state-of-the-art review of the general understanding of the process of tumor invasion. In addition, the articles emphasize specific aspects of aggressive brain cancers which are particularly important for deriving new insights for therapeutic approaches for advanced brain cancer that will target tumor invasiveness. The ideas discussed will stimulate further studies directed towards the translation of these important invasion-related studies to clinical approaches for the effective treatment of brain cancer.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Tumor invasion, proteolysis, and angiogenesis

    Thorgeirsson, Unnur P. (et al.)

    Pages 1-15

  • Matrix degrading metalloproteinases

    Ennis, Bruce W. (et al.)

    Pages 17-21

  • Tumoral invasion in the central nervous system

    Clerck, Yves A. (et al.)

    Pages 23-33

  • The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction

    Khokha, R. (et al.)

    Pages 35-39

  • Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model

    Rao, Jasti S. (et al.)

    Pages 41-50

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4615-2622-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-0-7923-2791-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4613-6124-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Brain Tumor Invasiveness
Editors
  • Ronald H. Goldfarb
Copyright
1994
Publisher
Springer US
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-1-4615-2622-3
DOI
10.1007/978-1-4615-2622-3
Hardcover ISBN
978-0-7923-2791-2
Softcover ISBN
978-1-4613-6124-4
Edition Number
1
Number of Pages
VIII, 82
Additional Information
Reprinted from JOURNAL OF NEURO-ONCOLOGY, 18:2
Topics