Brain Tumor Invasiveness

1. Front Matter

   Pages i-viii

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2. Tumor invasion, proteolysis, and angiogenesis

   • Unnur P. Thorgeirsson, Carol K. Lindsay, David W. Cottam, Daniel E. Gomez

   Pages 1-15

3. Matrix degrading metalloproteinases

   • Bruce W. Ennis, Lynn M. Matrisian

   Pages 17-21

4. Tumoral invasion in the central nervous system

   • Yves A. De Clerck, Hiroyuki Shimada, Ignacio Gonzalez-Gomez, Corey Raffel

   Pages 23-33

5. The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction

   • R. Khokha, P. Waterhouse

   Pages 35-39

6. Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model

   • Jasti S. Rao, Peter A. Steck, Philip Tofilon, Douglas Boyd, Francis Ali-Osman, William G. Stetler-Stevenson et al.

   Pages 41-50

7. Malignant melanoma metastasis to brain: role of degradative enzymes and responses to paracrine growth factors

   • Garth L. Nicolson, Motowo Nakajima, John L. Herrmann, David G. Menter, Philip G. Cavanaugh, June Sik Park et al.

   Pages 51-61

8. Migration of fresh human malignant astrocytoma cells into hydrated gel wafers in vitro

   • Jerald J. Bernstein, William J. Goldberg, Edward R. Laws Jr.

   Pages 63-73

9. Comparative aspects of neoplastic invasion of the brain

   • Hans E. Kaiser

   Pages 75-82

It is widely appreciated that the pathophysiology of advanced brain cancer is intimately related to the extent of tumor invasiveness. A prerequisite for comprehensively understanding neuro-oncology is therefore the elucidation of the biochemical and molecular properties of tumor cells that contribute to their invasiveness. An understanding of tumor invasion for central nervous system tumors is crucial since malignant brain tumors are very highly invasive and extensively destroy adjacent neural brain tissue. Moreover, they are angiogenesis-dependent and lead to the death of patients by expanding within the limited space of the cranium. As more specific insights are gained towards a full understanding of the complex process of tumor invasiveness of brain tumor cells, it should be possible to design strategies for the early diagnosis and treatment of invasive, advanced brain tumors. There is therefore an urgent need to better understand the cellular properties of brain tumor cells responsible for invasiveness.
This special issue of the JOURNAL OF NEURO-ONCOLOGY provides a state-of-the-art review of the general understanding of the process of tumor invasion. In addition, the articles emphasize specific aspects of aggressive brain cancers which are particularly important for deriving new insights for therapeutic approaches for advanced brain cancer that will target tumor invasiveness. The ideas discussed will stimulate further studies directed towards the translation of these important invasion-related studies to clinical approaches for the effective treatment of brain cancer.

• Grading
• angiogenesis
• brain
• brain tumor
• brain tumors
• central nervous system
• melanoma
• metastasis
• nervous system
• pathophysiology
• tumor

• Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, USA

  Ronald H. Goldfarb

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