Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

1. Front Matter

   Pages i-xxxi

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2. Phospholipid Turnover Oxygenases and Fatty Acid Metabolism

   1. Front Matter

      Pages 1-1

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   2. Immunobiochemical and Molecular Biological Studies on Arachidonate 12-Lipoxygenase of Porcine Leukocytes

      • S. Yamamoto, T. Yoshimoto, H. Suzuki, N. Ueda, K. Natsui, Y. Takahashi et al.

      Pages 3-8

   3. Transcellular Biosynthesis of Leukotrienes: Is Leukotriene A4 a Mediator?

      • R. C. Murphy, J. MacLouf, P. M. Henson

      Pages 9-14

   4. The Occurence of Thromboxane Synthase in Tumor Cells

      • R. Nüsing, V. Ullrich, F. Gudat, M. J. Mihatsch

      Pages 15-18

   5. Stimulation and Inhibition of Oxygen Radical Formation by Ascorbic Acid and 13-CIS-Retinoic Acid

      • L. J. Marnett, V. Samokyszyn, D. Laudicina

      Pages 19-25

   6. Fatty Acid Cyclooxygenase Metabolism of Arachidonic Acid in Human Tumor Cells

      • W. C. Hubbard, M. C. Alley, T. L. McLemore, M. R. Boyd

      Pages 27-32

   7. Identification of Linoleic Acid Metabolism as a Component of the Epidermal Growth Factor Signal Transduction Pathway in BALB/c 3T3 Fibroblasts

      • T. E. Eling, W. C. Glasgow

      Pages 33-36

   8. Localization and Expression of the Eicosanoid Metabolizing P4501VA Gene Family in Rat Tissues and Hepatic Tumors

      • J. P. Hardwick, J. J. Russell, S. Kimura, F. J. Gonzalez, J. K. Reddy, C. Peraino et al.

      Pages 37-41

   9. Deficient Lipoxin Formation in Chronic Myelogenous Leukemia

      • J. Å. Lindgren, C. Edenius, L. Stenke

      Pages 43-47

3. Radiation and Chemical Carcinogenesis

   1. Front Matter

      Pages 49-49

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   2. Radiation Injury and Carcinogenesis

      • A. R. Kennedy

      Pages 51-59

   3. Tumor Promotion and the Arachidonate Cascade

      • S. M. Fischer, G. S. Cameron, K. E. Patrick, J. Leyton, R. J. Morris

      Pages 61-67

   4. Eicosanoids and Bioactive Lipids as Modifiers of Multistage Carcinogenesis In Vitro

      • C. Borek

      Pages 69-72

   5. Prevention of Peroxide Produced DNA Strand Scission in Human Tumor Cells by Lipoxygenase Inhibitors

      • M. A. Baker

      Pages 73-77

   6. 8-Hydroxydeoxyguanosine, a DNA Adduct Formed by Oxygen Radicals: Its Implications on the Mutagenic and Carcinogenic Action of Oxygen Radical-Forming Agents

      • H. Kasai, M.-H. Chung, D. S. Jones, H. Inoue, H. Ishikawa, H. Kamiya et al.

      Pages 79-86

   7. Reaction of DNA Peroxyl Radicals with Cysteamine and Glutathione: The Formation of Sulfoxyl Radicals

      • M. D. Sevilla, M. Yan, D. Becker, S. Gillich

      Pages 87-91

   8. Fatty Acid-Induced Modulation of Carcinogenesis in Human and Mouse Mammary Explant Cultures

      • N. T. Telang, A. Basu, M. J. Modak, H. L. Bradlow, M. P. Osborne

      Pages 93-102

   9. Radiation Protection and Cancer Therapy by Linoleate

      • K. S. Iwamoto, L. R. Bennett, A. E. Villalobos, C. A. Hutson, W. H. McBride, A. Norman

      Pages 103-107

4. Lipid Peroxidation, Eicosanoid Biosynthesis, and Radiation Induced Tissue Injury

   1. Front Matter

      Pages 109-109

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This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The program consisted of 83 oral and 29 poster presentations, 74 of which are included in these proceedings. The major sponsors of the conference were the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland, the Radiation Oncology Research and Development Center of the Gershenson Radiation Oncology Center, Harper Hospital in Detroit, Michigan, and Schering AG of West Germany. Eighteen other organizations provided additional support. The conference was unique in its attempt to link the eicosanoid and lipid researchers in the radiobiology and cancer disciplines. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated scientific interaction to sort out and understand these complex and sometimes contradictory observations. The success of this effort is reflected not only through these proceedings, but also through the decision to continue the conference series with a second meeting to be held in Berlin between September 17-21, 1991.

• Tumor
• carcinogenesis
• cell
• cellular differentiation
• leukemia
• melanoma
• mutagen
• ovarian cancer
• prevention
• radiation
• radiation oncology
• radiotherapy
• thymus
• transplantation
• tumor growth
• Diagnostic Radiology

' The paradoxical roles of eicosanoids (stimulation/inhibition of injury processes) are the primary subjects of the investigations reviewed in this book. It will be of great interest to both researchers and clinicians.' Annals of Oncology 3:10 1992

• Department of Radiation Oncology, Wayne State University, Detroit, USA

  Kenneth V. Honn

• Department of Biochemistry, Vanderbilt University, Nashville, USA

  Lawrence J. Marnett

• Department of Gynecological Endocrinology Klinikum Steglitz, Free University Berlin, Berlin, Germany

  Santosh Nigam

• Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, USA

  Thomas L. Walden

Policies and ethics