Overview
- Editors:
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Noboru Kobayashi
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National Children’s Hospital, Setagaya-ku, Tokyo 154, Japan
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Tai Akera
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The National Children’s Hospital Medical Research Center, Tokyo, Japan
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Shuki Mizutani
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Department of Virology, The National Children’s Medical Research Center, Setagaya-ku, Tokyo 154, Japan
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Table of contents (28 papers)
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Biology of Childhood Leukemia
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- Melvyn F. Greaves, Li Chong Chan, Anthony M. Ford, Susan M. Pegram, Leanne M. Wiedemann
Pages 3-22
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- Makio Ogawa, Kenji Kishi, Jing Ping Shih
Pages 23-31
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- John C. Reed, Michael P. Cuddy, Subrata Haldar, Carlo Croce, Peter Nowell, David Makover et al.
Pages 43-50
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- Yasuhide Hayashi, Susana C. Raimondi, A. Thomas Look
Pages 59-68
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- Junichiro Fujimoto, Nobutaka Kiyokawa, Hiroo Fujita, Kazumi Imai, Yoshie Matsubayashi, Yasuo Kokai et al.
Pages 69-76
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- Shuki Mizutani, Kozue Nakamura, Toshiyuki Miyashita, Miwako Ozaki, Kouichi Miyamura’, Takao Matsuei’ et al.
Pages 77-86
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- Keisei Kawa-Ha, Akio Tawa, Keiko Yumura-Yagi, Junichi Hara, Shigehiko Ishihara
Pages 87-93
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Epidemiology of Childhood Leukemia
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- Jillian M. Birch, Valerie Blair
Pages 97-106
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Treatment of Childhood Leukemia
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Front Matter
Pages 127-127
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- Joseph V. Simone, Gaston K. Rivera, A. Thomas Look, William M. Crist
Pages 129-134
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- W. Archie Bleyer, David G. Poplack, Frank M. Balis
Pages 149-155
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- Masanori Yanai, Yoshiro Tsuji, Takeo Fujimoto
Pages 157-165
About this book
Twenty years ago when Children's Cancer Association of Japan was born, the diagnosis of childhood leukemia amounted to a death sentence. Only 20% or so of children with leukemia survived more than 5 years. Since then, enormous improvements have been achieved regarding our understanding on the etiology, diagnosis, and the treatment of childhood leukemia. Now, 70% of children with leukemia survive and enter adult life. Even though the improved survival rate of children with leukemia represents a medical success story, we now face new problems. The first problem is the fact that we still lose 20-30% of patients with childhood leukemia. To address this problem, we need to understand the etiology, epidemiology, and biology of leukemia; to identify the patients at greater risk; and to develop adequate treatments. The second problem is the treatment itself. Even though efficacious, the modem treatment for leukemia is a grueling experience for children and their families. We should develop a total care system for families and children based on a deep understanding of their needs. The third problem is the aftereffects of the treatment and of cured leukemia. Extensive radiation and chemotherapy have an entirely different spectrum of long-term effects on children than on adults. These treatments in the early stage of life, when the mind and body are developing, create many physical and psychological problems. These are the present problems of childhood leukemia.
Reviews
'Overall I found this an interesting collection of papers which well summarises the studies made in the treatment of children with cancer between the first and second symposia. It would be a worthwhile volume to have on the shelves of one's library and is relatively up to date despite the 2 year lag between meeting and publication.' Australian Cancer Society 16:2 1992
Editors and Affiliations
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National Children’s Hospital, Setagaya-ku, Tokyo 154, Japan
Noboru Kobayashi
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The National Children’s Hospital Medical Research Center, Tokyo, Japan
Tai Akera
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Department of Virology, The National Children’s Medical Research Center, Setagaya-ku, Tokyo 154, Japan
Shuki Mizutani