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Developments in Cardiovascular Medicine

Subcellular Basis of Contractile Failure

Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Society for Heart Research, May 11–13, 1989, Ottawa, Canada

Editors: Korecky, Borivoj, Dhalla, Naranjan S (Eds.)

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Hardcover $249.99
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  • ISBN 978-0-7923-0890-4
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Softcover $199.99
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About this book

This monograph contains 20 selected papers presented at the Symposium on Subcellular Basis of Contractile Failure which was held in Ottawa during May 11-13, 1989 and is designed for the benefit ofthose who were unable to attend this event. It is now increasingly becoming clear that an excessive amount of calcium is intimately involved in the pathogenesis of a wide variety of heart diseases. Accordingly, the investigations concerning the role of calcium chan­ nels and their regulatory mechanisms in heart function as well as of the intra­ cellular calcium overload in cardiac dysfunction are presented here. Since sodium is also considered to influence the cardiac contractile force by chang­ 2 ing the intracellular concentration of calcium through the Na +-Ca+ exchange 2 mechanism in the cell membrane, the role of Na +-Ca+ exchange in heart func­ tion as well as pathology of contractile failure is discussed. In view of the new­ ly discovered implications of the oxygen free radicals in cellular injury, papers concerning the role of these radicals in heart disease are included in this book. For the purpose of clarity, different chapters have been organized under three main headings: (I) Role of cations in heart function, (II) Cardiac hypertrophy and cardiomyopathies, and (III) Ischemic heart disease and cardiac failure.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • Role for Sodium Channels and Intracellular Sodium in Regulation of the Cardiac Force-Frequency Relation and Contractility

    Pages 3-17

    January, Craig T. (et al.)

  • Regulation of Cardiac Calcium Current during Suppression of Second Messenger Intracellular Enzymatic Pathways

    Pages 19-37

    Asai, T. (et al.)

  • Hormonal and Non-Hormonal Regulation of Ca2+ Current and Adenylate Cyclase in Cardiac Cells

    Pages 39-54

    Fischmeister, Rodolphe (et al.)

  • Calcium Current in Normal and Hypertrophied Isolated Rat Ventricular Myocytes

    Pages 55-67

    Scamps, F. (et al.)

  • Regulation of Contractile Activity in Single Adult Cardiomyocytes Isolated from Four Different Species: The Effect of Reduced Sodium Gradient

    Pages 69-83

    Horackova, M.

Buy this book

eBook $149.00
price for USA in USD
  • ISBN 978-1-4613-1513-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-0-7923-0890-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $199.99
price for USA in USD
  • ISBN 978-1-4612-8813-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Subcellular Basis of Contractile Failure
Book Subtitle
Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Society for Heart Research, May 11–13, 1989, Ottawa, Canada
Editors
  • Borivoj Korecky
  • Naranjan S Dhalla
Series Title
Developments in Cardiovascular Medicine
Series Volume
116
Copyright
1990
Publisher
Springer US
Copyright Holder
Kluwer Academic Publishers
eBook ISBN
978-1-4613-1513-1
DOI
10.1007/978-1-4613-1513-1
Hardcover ISBN
978-0-7923-0890-4
Softcover ISBN
978-1-4612-8813-8
Series ISSN
0166-9842
Edition Number
1
Number of Pages
X, 332
Topics