Regulatory Mechanisms in Breast Cancer
Advances in Cellular and Molecular Biology of Breast Cancer
Editors: Lippman, Marc E., Dickson, Robert B. (Eds.)
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- About this book
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In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.
- Reviews
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This book is excellent in overall quality. The book is an important and useful addition to the scientific literature. It provides a fresh perspective on breast cancer for students and for clinical and basic researchers alike.Journal of the Nat. Cancer
- Table of contents (20 chapters)
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Oncogenes as clinical prognostic indicators
Pages 3-22
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Role of the retinoblastoma gene in the oncogenesis of human breast carcinoma
Pages 23-44
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Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland
Pages 47-78
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Local effects of growth factors
Pages 79-92
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The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer
Pages 93-106
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Table of contents (20 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Regulatory Mechanisms in Breast Cancer
- Book Subtitle
- Advances in Cellular and Molecular Biology of Breast Cancer
- Editors
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- Marc E. Lippman
- Robert B. Dickson
- Series Title
- Cancer Treatment and Research
- Series Volume
- 53
- Copyright
- 1991
- Publisher
- Springer US
- Copyright Holder
- Kluwer Academic Publishers
- eBook ISBN
- 978-1-4615-3940-7
- DOI
- 10.1007/978-1-4615-3940-7
- Hardcover ISBN
- 978-0-7923-0868-3
- Softcover ISBN
- 978-1-4613-6758-1
- Series ISSN
- 0927-3042
- Edition Number
- 1
- Number of Pages
- IV, 452
- Topics
