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Pathophysiology of Severe Ischemic Myocardial Injury

  • Book
  • © 1990

Overview

Editors:
  1. Hans Michael Piper

    1. Institute of Physiology, University of Düsseldorf, Düsseldorf, Germany

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 104)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xii
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  3. The role of energy deficiency

    1. Front Matter

      Pages 25-25
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    2. The critical ATP threshold hypothesis

      • P. G. Spieckermann
      Pages 27-39

    3. Importance of glycolytically produced ATP for the integrity of the threatened myocardial cell

      • Lionel H. Opie
      Pages 41-65

  4. The search for critical cellular structures

    1. Front Matter

      Pages 67-67
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    2. Loss of sarcolemmal integrity in ischemic myocardium

      • Marcel Borgers
      Pages 69-89

    3. Mitochondrial injury in the oxygen-depleted and reoxygenated myocardial cell

      • Hans Michael Piper
      Pages 91-113

    4. Lysosomal integrity in ischemic, hypoxic and recovering heart

      • Robert S. Decker, Marlene L. Decker
      Pages 115-145

  5. The role of lipids

    1. Front Matter

      Pages 147-147
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    2. Detrimental effects of fatty acids and their derivatives in ischemic and reperfused myocardium

      • A. James Liedtke, Earl Shrago
      Pages 149-166

    3. Hydrolysis of phospholipids and cellular integrity

      • Ger J. Van Der Vusse, Marc Van Bilsen, Trudi Sonderkamp, Robert S. Reneman
      Pages 167-193

    4. Eicosanoids and the ischemic myocardium

      • K. Schrör, T. Hohlfeld
      Pages 195-217

  6. The role of oxygen radicals

    1. Front Matter

      Pages 219-219
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    2. Importance of free radicals generated by endothelial and myocardial cells in ischemia and reperfusion

      • R. Ferrari, S. Curello, A. Cargnoni, E. Condorelli, L. Comini, S. Ghielmi et al.
      Pages 221-238

    3. The role of leukocytes in ischemic damage, reperfusion injury and repair of the myocardium

      • Kevin M. Mullane, C. Wayne Smith
      Pages 239-267

    4. Problems associated with reperfusion of ischemic myocardium

      • Wolfgang Schaper, Jutta Schaper
      Pages 269-280

  7. The role of calcium

    1. Front Matter

      Pages 281-281
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Keywords

About this book

In industrialized countries, ischemic heart disease is by far the most common organ-specific cause of death. The thrombotic occlusion of a coronary artery which had previously been severely altered by atherosclerosis, is the most frequent cause of ischemic deterioration of myocardial tissue, i. e. myocardial infarction. Death of the human individual occurs when myocardial ischemia causes a critical impairment of cardiac pump function. The failure of a heart with an ischemic area may be due to the amount and location of contractile tissue becoming paralyzed or even necrotic, or to arrhythmias provoked by the ischemic condition, or by a combination of both factors. Considerable progress has been made in the development of antiarrythmic therapy. Effective tools have been developed to reperfuse ischemic myocar­ dial tissue as soon as the patient reaches hospital. However, therapeutical principles for the ischemic-reperfused myocardium which would specifically interfere with the state of injury of the ischemic tissue at the onset of reperfusion, and avoid the apparent hazards of the reperfusion process itself, have yet to be established. But not only approved therapeutical concepts are lacking, the pathophysiology of myocardial cell injury in pro­ gressive ischemia and under reperfusion is in itself only partly understood.

Reviews

`... it undoubtedly provides up-to-date knowledge and should prove a valuable source of reference.'
Cardiology Today, 19:1, 1991

Editors and Affiliations

  • Institute of Physiology, University of Düsseldorf, Düsseldorf, Germany

    Hans Michael Piper

Bibliographic Information

  • Book Title: Pathophysiology of Severe Ischemic Myocardial Injury

  • Editors: Hans Michael Piper

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-94-009-0475-0

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1990

  • Hardcover ISBN: 978-0-7923-0459-3Due: 31 March 1990

  • Softcover ISBN: 978-94-010-6699-0Published: 26 September 2011

  • eBook ISBN: 978-94-009-0475-0Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: 440

  • Topics: Cardiology

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