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Bile Acids in Health and Disease

Update on Cholesterol Gallstones and Bile Acid Diarrhoea

Editors: Northfield, T.C., Zentler-Munro, P., Jazwari, R. (Eds.)

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  • ISBN 978-94-009-1249-6
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Hardcover $99.00
price for USA in USD
  • ISBN 978-0-7462-0076-6
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  • This title is currently reprinting. You can pre-order your copy now.
Softcover $79.99
price for USA in USD
  • ISBN 978-94-010-7054-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Bile acids occupy a central position in in the absorption, excretion and metab­ olism of lipids within the body. Our understanding of their unique properties has illuminated many biochemical and biophysical processes. Animals have evolved a unique system of preserving these important detergent-like molecules within the body and reusing them many times - the enterohepatic circulation. Disorders of the enterohepatic circulation contribute to a correspondingly wide range of diseases, and recent developments have centred in particular on cholesterol gallstone disease and bile acid diarrhoea. Successful manage­ ment of these diseases is increasingly based on an understanding of the physicochemical and biochemical properties of bile acids, and of their pathophysiological role in disease. Professor Alan Hofmann starts this book with an overview of the enterohepatic circulation of bile acids. The first section then discusses biliary lipid synthesis, transport and secretion by the liver and the solubilisation of cholesterol in the bile. The next section applies this knowledge to the pathogenesis of cholesterol gallstones. Separate chapters focus on defects in biliary lipid secretion, in cholesterol solubilisation and in gallbladder motility. The succeeding sections then review posssible approaches to gallstone prevention, and assess recent developments in non-surgical forms oftreatment. Two exciting new therapies that receive particular attention are contact dissolution therapy with methyl tert-butyl ether and extracorporeal shock wave lithotripsy. Further sections turn to the absorptive functions of bile acids in health.

Table of contents (24 chapters)

  • Overview: Enterohepatic Circulation of Bile Acids — a Topic in Molecular Physiology

    Hofmann, A. F.

    Pages 1-18

  • Hepatic Bile Acid Transport and Secretion

    Erlinger, S.

    Pages 21-26

  • Hepatic Biliary Lipid Synthesis and Transport

    Graham, J. M. (et al.)

    Pages 27-41

  • Biliary Lipid Secretion and its Control

    Coleman, R. (et al.)

    Pages 43-60

  • Lipid Solubilisation in Bile

    Carey, M. C.

    Pages 61-82

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-94-009-1249-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA in USD
  • ISBN 978-0-7462-0076-6
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $79.99
price for USA in USD
  • ISBN 978-94-010-7054-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Bile Acids in Health and Disease
Book Subtitle
Update on Cholesterol Gallstones and Bile Acid Diarrhoea
Editors
  • T.C. Northfield
  • P. Zentler-Munro
  • R. Jazwari
Copyright
1988
Publisher
Springer Netherlands
Copyright Holder
Kluwer Academic Publishers
eBook ISBN
978-94-009-1249-6
DOI
10.1007/978-94-009-1249-6
Hardcover ISBN
978-0-7462-0076-6
Softcover ISBN
978-94-010-7054-6
Edition Number
1
Number of Pages
288
Topics