Emerging Targets in Antibacterial and Antifungal Chemotherapy

Editors: Sutcliffe, Joyce, Georgopapadakou, Nafsika (Eds.)

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About this book

Emerging Targets in Antibacterial and Antifungal Chemotherapy offers constructive ideas to researchers that could lead to the discovery of entirely new classes of drugs. The authors emphasize new topics rather than review work on known antibacterials and antifungals, and identify new targets--either the rate-limiting component of a biochemical pathway or a component of the pathway that is susceptible to a ``screening'' or ``rational drug design'' approach. Each chapter reviews the biochemical pathway and its place in the cellular scheme in order to place the target in perspective. The authors, a mixture of academic researchers and drug-discovery investigators in pharmaceutical companies, also extend these theoretical concerns into practical applications and suggest useful screening methodologies. The importance of this subject area is demonstrated by the increasing number of papers in the literature that point to potential targets and screening methodologies for new antibacterials. This book also deals with antifungals, investigating the inherent limitations in existing antifungals (many of which are extremely toxic or have only limited efficacy), and pointing to major developments in the discovery of novel antifungals. Emerging Targets in Antibacterial and Antifungal Chemotherapy will be of interest to professional microbiologists, biochemists, and cell biologists in both academic and industrial laboratories.

Reviews

This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School; This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School; This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School

Table of contents (22 chapters)

  • Historical Perspectives of Approaches to Antibiotics Discovery

    Imada, Akira (et al.)

    Pages 1-23

  • Bacterial Pathogens for the 1990s: A Case for New Drug Development

    Drusano, George L.

    Pages 24-36

  • DNA Replication

    McHenry, Charles S.

    Pages 37-67

  • RNA Synthesis in Bacteria: Mechanism and Regulation of Discrete Biochemical Events at Initiation and Termination

    Das, Asis (et al.)

    Pages 68-116

  • Bacterial Cell Division

    Lutkenhaus, Joe

    Pages 117-150

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-1-4615-3274-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-0-412-02711-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-1-4613-6440-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Emerging Targets in Antibacterial and Antifungal Chemotherapy
Editors
  • Joyce Sutcliffe
  • Nafsika Georgopapadakou
Copyright
1992
Publisher
Springer US
Copyright Holder
Routledge, Chapman & Hall, Inc.
eBook ISBN
978-1-4615-3274-3
DOI
10.1007/978-1-4615-3274-3
Hardcover ISBN
978-0-412-02711-6
Softcover ISBN
978-1-4613-6440-5
Edition Number
1
Number of Pages
XVII, 606
Topics