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Biological and Medical Physics, Biomedical Engineering

Cellular Signaling in Health and Disease

Authors: Beckerman, Martin

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  • Summarizes the functioning of complex signaling pathways in different tissues and organs of the body in both health and disease
  • Provides insights into the underlying biophysical processes, the associated stable states, and the quantitative methods used for their study
  • Presents the latest research findings as a guide to drug design and tissue engineering
  • Contains over 150 figures illustrating the signalling networks and their operation
  • Includes extensive use of tables to summarize experimental results
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eBook $149.00
price for USA in USD (gross)
  • ISBN 978-0-387-98173-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-387-98172-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-1-4419-3109-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease.

The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

Table of contents (20 chapters)

Table of contents (20 chapters)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-0-387-98173-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-387-98172-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-1-4419-3109-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cellular Signaling in Health and Disease
Authors
Series Title
Biological and Medical Physics, Biomedical Engineering
Copyright
2009
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-98173-4
DOI
10.1007/978-0-387-98173-4
Hardcover ISBN
978-0-387-98172-7
Softcover ISBN
978-1-4419-3109-2
Series ISSN
1618-7210
Edition Number
1
Number of Pages
XVIII, 470
Number of Illustrations
193 b/w illustrations
Topics