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Animal Models in Cardiovascular Research

Authors: Gross, David

  • The first two editions of this standard reference text have been cited well over 150 times, according to SCI
  • An expanded first chapter will include more information on the cardiovascular effects of post-operative analgesia
  • Will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-0-387-95962-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-387-95961-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4419-3070-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Animal Models in Cardiovascular Research covers both historical and recent advances in our understanding of the cardiovascular system from studies conducted in animal models. The last decade has seen an explosion in the use of very specialized congenic and transgenic animal models that were not described in the previous two editions. The results of many of these studies provide a sometime bewildering array of redundant, overlapping and competing molecular pathways demanding further study. This third edition is designed to provide a better basis for understanding and using animal models in the current climate of background knowledge and information.

The first and second editions of Animal Models in Cardiovascular Research emphasized normal cardiovascular parameters and the cardiovascular effects of a wide variety of drugs commonly used for restraint, anesthesia and pain control in the various animal species. The third edition is focused on the avalanche of genetic, molecular and protein-based information generated from the use of both congenic and transgenic animal models. Updated and expanded chapters provide new information generated from classical, congenic and transgenic animal models used to study ischemic heart disease, cardiomyopathy, heart failure, hypertension and atherosclerotic disease.

Completely new chapters in this third edition describe the techniques, problems and pitfalls associated with the measurement of cardiac and vascular function and ventricular/arterial coupling dynamics in various animal models. There is a new chapter detailing problems and pitfalls associated with isolated heart preparations and another describing animal models for the study of neurohumeral and CNS control of the cardiovascular system.

About the authors

Dr. David R. Gross entered private veterinary practice after earning the DVM degree from Colorado State University in 1960. In 1974 he was awarded the PhD degree in physiology from the Ohio State University beginning a 36-year career in academics that culminated as professor and head of the Department of Veterinary Biosciences in the College of Veterinary Medicine, University of Illinois, Urbana-Champaign. Dr. Gross’ research career encompassed 58 funded projects totaling over $5.5 million and 91 papers published in refereed journals using a wide variety of animal models. Ironically his three most-cited research papers received no external funding. He and his colleagues showed that feeding dietary cholesterol to rabbits induced Alzheimer’s-like lesions in the brain. Their work also showed that surgery involving cardiopulmonary bypass resulted in Alzheimer’s-like brain lesions in pigs. With another group of colleagues he helped pioneer minimally invasive coronary artery bypass grafting techniques using the pig as a model.

Table of contents (14 chapters)

  • General Principles of Animal Selection and Normal Physiological Values

    Gross, David R.

    Pages 1-15

  • Preanesthesia, Anesthesia, Chemical Restraint, and the Recognition and Treatment of Pain and Distress

    Gross, David R.

    Pages 17-54

  • Normal Cardiac Function Parameters

    Gross, David R.

    Pages 55-64

  • Measuring Cardiac Function

    Gross, David R.

    Pages 65-91

  • Measuring Vascular Function and Ventricular/Arterial Coupling Dynamics

    Gross, David R.

    Pages 93-108

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-0-387-95962-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-387-95961-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4419-3070-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Animal Models in Cardiovascular Research
Authors
Copyright
2009
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-95962-7
DOI
10.1007/978-0-387-95962-7
Hardcover ISBN
978-0-387-95961-0
Softcover ISBN
978-1-4419-3070-5
Edition Number
3
Number of Pages
XXVI, 431
Additional Information
Originally published as volume 153 in the series: Developments in Cardiovascular Medicine
Topics