Pathology of Multiple Pregnancy

1. Front Matter

   Pages i-xv

   PDF

2. Introduction and Twin Studies

   • Virginia J. Baldwin

   Pages 1-7

3. Twinning Mechanisms and Zygosity Determination

   • Virginia J. Baldwin

   Pages 9-28

4. The Placenta in Multiple Pregnancy

   • Virginia J. Baldwin

   Pages 29-62

5. Obstetric Aspects of Multiple Pregnancy

   • Virginia J. Baldwin

   Pages 63-85

6. Mortality of Twins

   • Virginia J. Baldwin

   Pages 87-132

7. Morbidity of Twins

   • Virginia J. Baldwin

   Pages 133-167

8. Anomalous Development of Twins

   • Virginia J. Baldwin

   Pages 169-197

9. The Pathology of Monochorionic Monozygosity

   • Virginia J. Baldwin

   Pages 199-213

10. Intertwin Vascular Anastomoses

    • Virginia J. Baldwin

    Pages 215-275

11. Anomalies of Monozygotic Duplication

    • Virginia J. Baldwin

    Pages 277-347

12. Triplets and Higher Multiples

    • Virginia J. Baldwin

    Pages 349-386

13. Back Matter

    Pages 387-409

    PDF

Pathology of Multiple Pregnancy collates case material from over 500 autopsies (including embryos) and 1200 placentas from twins, triplets, and higher multiples with selected literature on human multiple reproduction. It emphasizes important new concepts of pathophysiology and interpretation of less than ideal outcomes of multiple conception based on over 30 years experience in the field. Aspects of perinatal pathology unique to twins and higher multiples are emphasized, with practical suggestions for the service pathologist, including items of potential medico-legal significance. Controversial topics, such as the value of studies of concordance for diseases or malformations, and the significance of inter-twin anastomoses, are addressed and suggestions made for further investigation. A close working relationship between pathologists and clinical colleagues is encouraged by discussion of clinico-pathological correlations. And, the most recent discussions on mechanisms of twinning and genetic versus environmental influences on the development of twins are presented.

• Embryo
• pathophysiology
• placenta
• pregnancy
• reproduction

"This book is close to art... The discussion of the mechanism of twinning and the ambiguity of zygosity should be mandatory readings for all who interpret or cite twin studies..." (NEJM)
"Well-written and clinically relevant, Dr. Baldwin's book engages readers with an in-depth lucid and scholarly presentation..." (Mayo Clinica Proceedings)

• Department of Pathology, British Columbia’s Children’s Hospital, Vancouver, Canada

  Virginia J. Baldwin

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