Dynamic-Clamp
From Principles to Applications
Editors: Destexhe, Alain, Bal, Thierry (Eds.)
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- About this book
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Dynamic-clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models. The dynamic-clamp (also called "conductance injection") allows experimentalists and theoreticians to challenge neurons (or any other type of cell) with complex conductance stimuli generated by a computer.
The technique can be implemented from neural simulation environments and a variety of custom-made or commercial systems. The real-time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode. Dynamic- Clamp: From Principles to Applications contains contributions from leading researchers in the field, who investigate these paradigms at the cellular or network level, in vivo and in vitro, and in different brain regions and cardiac cells. Topics discussed include the addition of artificially-generated synaptic activity to neurons; adding, amplifying or neutralizing voltage-dependent conductances; creating hybrid networks with real and artificial cells; attaching simulated dendritic tree structures to the living cell; and connecting different neurons.
This book will be of interest to experimental biophysicists, neurophysiologists, and cardiac physiologists, as well as theoreticians, engineers, and computational neuroscientists. Graduate and undergraduate students will also find up-to-date coverage of physiological problems and how they are investigated.
About the Editors:
Dr. Alain Destexhe and Dr. Thierry Bal are Research Directors at the Centre National de la Recherche Scientifique (CNRS), a governmental research institution in France. Their laboratories are located in the CNRS campus of Gif-sur-Yvette in the UNIC (Unité de Neurosciences Intégratives et Computationnelles) research unit. This campus is solely devoted to research and provides an ideal environment for close interaction between theory and experiments, as exemplified by the numerous publications on dynamic-clamp experiments co-authored by Dr. Bal and Dr. Destexhe. Each editor holds Ph.D.s in biophysics and neurobiology, respectively. Dr. Destexhe is also Chief Editor of the Journal of Computational Neuroscience.
- About the authors
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Dr. Alain Destexhe and Dr.Thierry Bal, are Research Directors at the Centre National de la Recherche Scientifique (CNRS), a governmental research institution in France. Their laboratories are located in the CNRS campus of Gif-sur-Yvette in the research unit (Unité de Neurosciences Intégratives et Computationnelles, UNIC). Gif-sur-Yvette is solely devoted to research and provides an ideal environment for close interaction between theory and experiments, as exemplified by the numerous publications on dynamic-clamp experiments co-authored by Bal and Destexhe. Each editor holds Ph.D.s in both biophysics and neurobiology, respectively. Dr. Destexhe is also Chief Editor of the Journal of Computational Neuroscience.
- Table of contents (18 chapters)
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Associating Living Cells and Computational Models: an Introduction to Dynamic Clamp Principles and its Applications
Pages 1-30
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Dendritic Dynamic Clamp – A Tool to Study Single Neuron Computation
Pages 31-47
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Synaptic Conductances and Spike Generation in Cortical Cells
Pages 49-71
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Simulating In Vivo Background Activity in a Slice with the Dynamic Clamp
Pages 73-87
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Impact of Background Synaptic Activity on Neuronal Response Properties Revealed by Stepwise Replication of In Vivo-Like Conditions In Vitro
Pages 89-114
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Table of contents (18 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Dynamic-Clamp
- Book Subtitle
- From Principles to Applications
- Editors
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- Alain Destexhe
- Thierry Bal
- Series Title
- Springer Series in Computational Neuroscience
- Series Volume
- 1
- Copyright
- 2009
- Publisher
- Springer-Verlag New York
- Copyright Holder
- Springer-Verlag New York
- eBook ISBN
- 978-0-387-89279-5
- DOI
- 10.1007/978-0-387-89279-5
- Hardcover ISBN
- 978-0-387-89278-8
- Softcover ISBN
- 978-1-4419-2790-3
- Series ISSN
- 2197-1900
- Edition Number
- 1
- Number of Pages
- XIV, 429
- Number of Illustrations
- 60 b/w illustrations
- Topics
