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Dendritic Cells in Cancer

  • Book
  • © 2009

Overview

Editors:
  1. Russell D. Salter
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    You can also search for this editor in PubMed   Google Scholar

  2. Michael R. Shurin
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    You can also search for this editor in PubMed   Google Scholar

  • Presents the very first analysis of published and not-yet published experimental and clinical data related to the immunobiology of DC in tumor-bearing hosts

  • No other publication combines all issues related to immunobiology of DC in cancer in one rationally organized comprehensive volume prepared by the leading experts in the field

  • Includes supplementary material: sn.pub/extras

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. ALTERATIONS OF THE DENDRITIC CELL SYSTEM IN CANCER

    1. Front Matter

      Pages 1-1
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    2. The Central Role of Dendritic Cells in Immunity

      • Jessica Chu, Russell D. Salter
      Pages 1-10

    3. Dendritic Cells in Cancer: Emergenceof the Discipline

      • Michael R. Shurin, Michael T. Lotze
      Pages 11-30

    4. Tumor-Infiltrating Dendritic Cells: The Pathologist’s Perspective

      • Dmitry W. Gutkin
      Pages 33-55

    5. Functional Defects of Dendritic Cells in Cancer

      • Mikhail M. Dikov, Irina S. Chekneva
      Pages 57-75

    6. General Properties of Dendritic Cell Populations in Cancer

      • Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, Tyler J. Curiel
      Pages 77-87

    7. Elimination of Dendritic Cells in Cancer

      • Viktor Umansky, Dirk Schadendorf
      Pages 89-99

  3. Mechanisms of Dendritic Cell Dysfunction in Cancer

    1. Front Matter

      Pages 1-1
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    2. Tumor-Derived Factors Responsible for Dendritic Cell Dysfunction

      • Alberto Pinzon-Charry, J. Alejandro López
      Pages 103-117

    3. Tumor-Derived Exosomes as Dendritic Cell Modulators

      • Roberta Valenti, Veronica Huber, Paola Filipazzi, Manuela Iero, Giorgio Parmiani, Licia Rivoltini
      Pages 119-128

    4. Signaling Pathways Mediating Dendritic Cell Dysfunction in Cancer

      • Jing Yang, Qing Yi
      Pages 129-142

    5. A Role for STAT3 in Dendritic Cell Regulation by Tumor-Derived Factors

      • Dmitry I. Gabrilovich
      Pages 143-155

    6. Tumor-Associated Inflammation and Impact on Dendritic Cell Function

      • Zoltan Pos, Marianna Sabatino, Tara Spivey, Hui Liu, Andras Falus, Francesco M. Marincola
      Pages 157-170

    7. Changes in Dendritic Cells in Cancer and Aging

      • Annabelle Grolleau-Julius, Raymond L. Yung
      Pages 171-180

    8. Stress, Immunity and Dendritic Cells in Cancer

      • Rachel Kohman, Alexander W. Kusnecov
      Pages 181-199

    9. Cancer Therapy and Dendritic Cell Immunomodulation

      • Galina V. Shurin, Neil Amina, Michael R. Shurin
      Pages 201-216

  4. Role of Dendritic Cells in Tumor Escape

    1. Front Matter

      Pages 1-1
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    2. Role of IDO in Dendritic Cell Differentiation and Function in Cancer

      • Alexey Popov, Joachim L. Schultze
      Pages 219-229

    3. Dendritic Cells: From Inducers of Specific T-Cell Responses to Promoters of Angiogenesis

      • George Coukos, Fabian Benencia
      Pages 231-241
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Keywords

About this book

It covers all aspects of DC generation, function, survival and antitumor activity in the tumor environment both in vivo and in experimental in vitro systems. The goal in focusing on a spectrum of issues related to DC in cancer is to provide an extensive and expansive review rather than a collection of independent analyses from different authors.

Specific topics to be covered include analysis of DC behavior in the tumor microenvironment, including endogenous and exogenous DC, multiple DC populations, molecular pathways responsible for DC dysfunction, tumor-derived factors altering DC polarization and activation, mechanisms of DC alterations, and the role of DC in tumor escape from immune recognition and elimination. Furthermore, additional chapters provide extensive analysis of the consequences of cancer therapy on the DC system and how aging impacts DC function in the tumor microenvironment. Finally, chapters are included examining strengths and pitfalls of current methodologies for generating DC from cancer patients for therapeutic purposes and on the role of tumor-mediated modulation of the DC system in cancer immunotherapy.

Bibliographic Information

  • Book Title: Dendritic Cells in Cancer

  • Editors: Russell D. Salter, Michael R. Shurin

  • DOI: https://doi.org/10.1007/978-0-387-88611-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2009

  • Hardcover ISBN: 978-0-387-88610-7Published: 14 April 2009

  • Softcover ISBN: 978-1-4419-2784-2Published: 29 October 2010

  • eBook ISBN: 978-0-387-88611-4Published: 20 April 2009

  • Edition Number: 1

  • Number of Pages: XVIII, 396

  • Number of Illustrations: 26 b/w illustrations

  • Topics: Cancer Research, Cell Biology, Pharmacology/Toxicology

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