Advances in Experimental Medicine and Biology

Current Topics in Complement II

Editors: Lambris, John D. (Ed.)

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  • Proceedings from the Fourth Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10-15, 2007)

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  • ISBN 978-0-387-78952-1
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About this book

Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or Inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspective. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits.

In this respect, scientists from around the world convened at the Fourth Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10-15, 2007), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the “novel” functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.

Table of contents (21 chapters)

Table of contents (21 chapters)
  • Adipokines and the Immune System: An Adipocentric View

    Pages 1-21

    MacLaren, Robin (et al.)

  • The Role of Complement in Stroke Therapy

    Pages 22-32

    Komotar, Ricardo J. (et al.)

  • Food Intake Regulation by Central Complement System

    Pages 33-44

    Ohinata, Kousaku (et al.)

  • A Pivotal Role of Activation of Complement Cascade (CC) in Mobilization of Hematopoietic Stem/Progenitor Cells (HSPC)

    Pages 45-58

    Ratajczak, Mariusz Z. (et al.)

  • Regulation of Tissue Inflammation by Thrombin-Activatable Carboxypeptidase B (or TAFI)

    Pages 59-67

    Leung, Lawrence L.K. (et al.)

Buy this book

eBook $179.00
price for USA in USD
  • ISBN 978-0-387-78952-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $279.99
price for USA in USD
Softcover $229.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Current Topics in Complement II
Editors
  • John D. Lambris
Series Title
Advances in Experimental Medicine and Biology
Series Volume
632
Copyright
2008
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-78952-1
DOI
10.1007/978-0-387-78952-1
Hardcover ISBN
978-0-387-78951-4
Softcover ISBN
978-1-4419-2706-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXX, 307
Number of Illustrations
65 b/w illustrations
Topics