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Recent Advances In Retinal Degeneration

  • Book
  • © 2008

Overview

Editors:
  1. Robert E. Anderson

    1. University of Oklahoma Health Science Ctr, Oklahoma City, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Matthew M. LaVail

    1. USCF School of Medicine, San Francisco, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Joe G. Hollyfield

    1. Cole Eye Institute The Cleveland Clinic Foundation, Cleveland, USA

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  • Special focus on mechanism of photoreceptor degeneration and cell death
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 613)

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Table of contents (48 chapters)

  1. Front Matter

    Pages I-XXXIV
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  2. Keynote Lectures

    1. Front Matter

      Pages 1-1
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    2. Curing Blindness with Stem Cells: Hope, Reality, and Challenges

      • Ruben Adler
      Pages 3-20

    3. Retinal Degenerations: Planning for the Future

      • Eliot L. Berson
      Pages 21-35

  3. Neuroprotection

    1. Front Matter

      Pages 37-37
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    2. Neurotrophins Induce Neuroprotective Signaling in the Retinal Pigment Epithelial Cell by Activating the Synthesis nl of the Anti-inflammatory and Anti-apoptotic Neuroprotectin D1

      • Nicolas G. Bazan
      Pages 39-44

    3. On the Role of CNTF as a Pontential Therapy for Retinal Degeneration: Dr. Jekyll or Mr. Hyde?

      • William A. Beltran
      Pages 45-51

    4. Nanoceria Particles Prevent ROI-Induced Blindness

      • Junping Chen, Swanand Patil, Sudipta Seal, James F. McGinnis
      Pages 53-59

    5. An in-vivo Assay to Identify Compounds Protective Against Light Induced Apoptosis

      • Yogita Kanan, Anne Kasus Jacobi, Kjell Sawyer, David S. Mannel, Joyce Tombran Tink, Muayyad R. Al-Ubaidi
      Pages 61-67

    6. Role of BCL-XL in Photoreceptor Survival

      • Yun-Zheng Le, Lixin Zheng, Yuwei Le, Edmund B. Rucker III, Robert E. Anderson
      Pages 69-74

    7. The Hypoxic Transcriptome of the Retina: Identification of Factors with Potential Neuroprotective Activity

      • Markus Thiersch, Wolfgang Raffelsberger, Enrico Frigg, Marijana Samardzija, Patricia Blank, Olivier Poch et al.
      Pages 75-85

  4. Gene Therapy and Neuroprotection

    1. Front Matter

      Pages 87-87
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    2. Lentiviral Gene Transfer-Mediated Cone Vision Restoration in RPE65 Knockout Mice

      • Alexis-Pierre Bemelmans, Corinne Kostic, Maité Cachafeiro, Sylvain V. Crippa, Dana Wanner, Meriem Tekaya et al.
      Pages 89-95

    3. In vitro Analysis of Ribozyme-mediated Knockdown of an ADRP Associated Rhodopsin Mutation

      • Dibyendu Chakraborty, Patrick Whalen, Alfred S. Lewin, Muna I. Naash
      Pages 97-106

    4. Gene Therapy for Mouse Models of ADRP

      • Marina S. Gorbatyuk, William W. Hauswirth, Alfred S. Lewin
      Pages 107-112

    5. Development of Viral Vectors with Optimal Transgene Expression for Ocular Gene Therapies

      • Takao Hashimoto
      Pages 113-119

    6. Adeno-Associated Viral Vectors and the Retina

      • John J. Alexander, William W. Hauswirth
      Pages 121-128

    7. Genetic Supplementation of RDS Alleviates a Loss-of-function Phenotype in C214S Model of Retinitis Pigmentosa

      • May Nour, Steven J. Fliesler, Muna I. Naash
      Pages 129-138

    8. of the Retina in the 4 Years Following rAAV-mediated Gene Transfer in the RPE65 Null Mutation Dog

      • Kristina Narfstrô m, Mathias Seeliger, Chooi-May Lai, Vaegan, Martin Katz, Elizabeth P. Rakoczy et al.
      Pages 139-146

    9. Virus-mediated Gene Delivery to Neuronal Progenitors

      • Tonia S. Rex
      Pages 147-153
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Keywords

About this book

Retinal Degenerations is the result of The International Symposium on Retinal Degeneration which has become perhaps the most important research meeting in the field. The topics in this volume explore the etiology, cellular mechanisms, epidemiology, generics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.

Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early of congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.

Reviews

From the reviews:

"This edited book is the proceedings of the symposium on Retinal Degeneration … . The purpose is to disseminate the latest research findings in the field of retinal degenerations from the symposium participants … . The book is written for scientists and trainees in the field of retinal degenerations. The editors are experts in this field and many of the chapter authors are experts in their respective areas. … This is a must-have reference for the shelf of scientists interested in retinal degeneration." (Artur V Cideciyan, Doody’s Review Service, April, 2008)

Editors and Affiliations

  • University of Oklahoma Health Science Ctr, Oklahoma City, USA

    Robert E. Anderson

  • USCF School of Medicine, San Francisco, USA

    Matthew M. LaVail

  • Cole Eye Institute The Cleveland Clinic Foundation, Cleveland, USA

    Joe G. Hollyfield

Bibliographic Information

  • Book Title: Recent Advances In Retinal Degeneration

  • Editors: Robert E. Anderson, Matthew M. LaVail, Joe G. Hollyfield

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-0-387-74904-4

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2008

  • Hardcover ISBN: 978-0-387-74902-0Published: 18 December 2007

  • Softcover ISBN: 978-1-4419-2577-0Published: 29 November 2010

  • eBook ISBN: 978-0-387-74904-4Published: 03 December 2007

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXXIV, 424

  • Number of Illustrations: 114 b/w illustrations, 3 illustrations in colour

  • Topics: Ophthalmology

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