Integration in Respiratory Control

1. Front Matter

   Pages i-xxxi

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2. Historical and Future Perspectives of the Control of Breathing

   1. History of Measuring O2 and CO2 Responses

      • John W. Severinghaus

      Pages 3-8

   2. J.S. Haldane and Some of His Contributions to Physiology

      • John B. West

      Pages 9-15

   3. Control of the Exercise Hyperpnea: The Unanswered Question

      • Brian J. Whipp

      Pages 16-21

3. Oxygen Sensing and the Carotid Body

   1. A Peripheral Oxygen Sensor Provides Direct Activation of an Identified Respiratory CPG Neuron in Lymnaea

      • Harold J. Bell, Takuya Inoue, Naweed I. Syed

      Pages 25-29

   2. Environmental Hyperoxia and Development of Carotid Chemoafferent Function

      • Gerald Bisgard, Julie Wenninger, Zunyi Wang, E. Burt Olson Jr.

      Pages 30-34

   3. HSP70 Reduces Chronic Hypoxia-Induced Neural Suppression via Regulating Expression of Syntaxin

      • Guanghe Fei, Conghui Guo, Hong-Shuo Sun, Zhong-Ping Feng

      Pages 35-40

   4. Effect of Systemic Administration of the Nitric Oxide Synthase Inhibitor L-NMMA on the Human Ventilatory Response to Hypoxia

      • Kojiro Ide, Matthew Worthley, Todd Anderson, Marc J. Poulin

      Pages 41-45

   5. Effects of Volatile Anesthetics on Carotid Body Response to Hypoxia in Animals

      • Jaideep J. Pandit, Kevin O’Gallagher

      Pages 46-50

   6. Mutation of the von Hippel-Lindau Gene Alters Human Cardiopulmonary Physiology

      • T. G. Smith, J. T. Brooks, G. M. Balanos, T. R. Lappin, D. M. Layton, D. L. Leedham et al.

      Pages 51-56

   7. Intravenous Endothelin-1 and Ventilatory Sensitivity to Hypoxia in Humans

      • Nick P. Talbot, George M. Balanos, Peter A. Robbins, Keith L Dorrington

      Pages 57-62

   8. Key Roles for AMP-activated Protein Kinase in the Function of the Carotid Body?

      • Christopher N. Wyatt, Selina A. Pearson, Prem Kumar, Chris Peers, D. Grahame Hardie, A. Mark Evans

      Pages 63-68

   9. Stimulatory Actions of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Rat Carotid Glomus Cells

      • Fenglian Xu, Frederick W. Tse, Amy Tse

      Pages 69-74

   10. Post-hypoxic Unstable Breathing in the C57BL/6J Mouse: Effects of Acetazolamide

       • Motoo Yamauchi, Jesse Dostal, Kingman P. Strohl

       Pages 75-79

4. Respiratory Rhythm Generation

   1. Catecholaminergic Modulation of the Respiratory Rhythm Generator in the Isolated Brainstem—Spinal Cord Preparation from Neonatal Rat

      • Akiko Arata, Morimitsu Fujii

      Pages 83-87

   2. What Role Do Pacemakers Play in the Generation of Respiratory Rhythm?

      • Christopher A. Del Negro, Ryland W. Pace, John A. Hayes

      Pages 88-93

   3. Pre-Bötzinger Complex Neurokinin-1 Receptor Expressing Neurons in Primary Cell Culture

      • Shereé M. Johnson

      Pages 94-98

   4. Belt-and-Suspenders as a Biological Design Principle

      • Nicholas M. Mellen

      Pages 99-103

   5. Two Modes of Respiratory Rhythm Generation in the Newborn Rat Brainstem-Spinal Cord Preparation

      • Hiroshi Onimaru, Ikuo Homma

      Pages 104-108

   6. Possible Roles of the Weakly Inward Rectifying K+ Channel Kir4.1 (KCNJ10) in the Pre-Bötzinger Complex

      • Nestoras Papadopoulos, Stefan M. Winter, Kai Härte, Melanie Kaiser, Clemens Neusch, Swen Hülsmann

      Pages 109-113

Like the geological treasures that surely must lie below the Athabasca glacier, some of the answers to key questions about the control of respiration remain buried. But bit by bit, year by year the ice is melting and perhaps in some areas the rocks are starting to be revealed. With a mission to advance our understanding of the emerging th th gems of respiration, the X Oxford Conference was held between 19–24 September (2006) next to the turquoise and tranquil waters of Lake Louise, in the middle of Banff National Park, Alberta, Canada. Since its inauguration 30 years ago in Oxford, the Oxford Conference on mo- ling and control of breathing has been held every three years in locations spanning the globe (a list of past conferences and publications that have emerged is included in the pages that follow). The series has provided key opportunities for respiratory scientists to meet with colleagues, discuss recent advances and celebrate their field. The 2006 Lake Louise meeting was Canada’s second Oxford Conference; the th previous Canadian meeting (the VII Oxford Conference) was held in 1997 at the Grandview Inn in Huntsville (Ontario) and was chaired by Richard Hughson, David Cunningham and Jim Duffin.

• Asthma
• Parkinson
• biomedical engineering
• brainstem
• pathophysiology
• physiology
• regulation
• respiration
• genetic engineering

From the reviews:

"This excellent resource for researchers working in the area of respiratory control is full of original work presented at the 10th Oxford conference held in 2006 in Lake Louise, Alberta, Canada. … Researchers and clinicians in pulmonary and sleep medicine will find this book valuable, as will respiratory physiologists, students, and trainees in pulmonary diseases. … This is a good referral resource for researchers who are actively working in the field of respiratory control." (K. P. Ravikrishnan, Doody’s Review Service, October, 2008)

• University of Calgary, Calgary, Canada

  Marc J. Poulin, Richard J. A. Wilson

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