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Mucosal Immune Defense: Immunoglobulin A

Editors: Kaetzel, Charlotte S. (Ed.)

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  • The very first publication to specifically address the role of IgA in mucosal defense immunology
  • Chapters have been contributed by internationally recognized leaders in the field of IgA research
  • This key work in the field draws on a broad spectrum of molecular biologic, biochemical, and immunogenetic approaches
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eBook $129.00
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  • ISBN 978-0-387-72232-0
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Hardcover $219.99
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  • ISBN 978-0-387-72231-3
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Softcover $169.99
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  • ISBN 978-1-4419-4427-6
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About this book

Antibodies of the IgA class form the front line of immune defense at mucosal surfaces lining the gastrointestinal, respiratory and genital tracts. These IgA antibodies promote peaceful co-existence with beneficial microorganisms, such as gut bacteria that assist in digestion and nutrient production, while selectively neutralizing pathogenic microorganisms and harmful environmental substances. This book, authored by international experts in the field of IgA immunology, presents a comprehensive and timely overview of current knowledge of IgA structure and function. Topics include the basic science of IgA biochemistry and molecular biology, general and tissue-specific aspects of IgA function, and the clinical relevance of IgA in infection, autoimmunity, immunodeficiency and cancer. The final chapters describe state-of-the art applications of molecular genetics for the production of vaccines and therapeutics targeting IgA. The unique focus on IgA, the most abundant molecule in the mucosal immune system, differentiates this book from more general texts in the area of mucosal immunology. This book should be useful for researchers, educators, clinicians and students interested in a concise source of up-to-date information on the central role of IgA in mucosal immune defense.

About the authors

Dr. Charlotte Kaetzel received her PhD and postdoctoral training in biochemistry and cell biology from the University of Maryland. Her introduction into the world of immunology came with her first faculty appointment in 1983 in the Department of Pathology at Case Western Reserve University in Cleveland. Under the mentorship of department chair Michael Lamm, a world leader in IgA biology, she applied the emerging tools of biochemistry and molecular biology to the study of IgA transport across epithelial cells of the gastrointestinal and respiratory tracts. Now a professor in the Department of Microbiology, Immunology and Molecular Genetics at the University of Kentucky College of Medicine, Dr. Kaetzel’s research is devoted to understanding the basic science and clinical relevance of IgA in maintenance of homeostasis in the gastrointestinal tract. Her research has been funded by the National Institutes of Health and the Crohn’s and Colitis Foundation of America. Dr. Kaetzel has served on advisory panels for a number governmental agencies and private foundations, and as an Associate Editor for The Journal of Immunology, the official journal of the American Association of Immunologists. A charter member of the Society for Mucosal Immunology, Dr. Kaetzel is currently serving as Associate Editor for its flagship journal, Mucosal Immunology.

Table of contents (15 chapters)

Table of contents (15 chapters)

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-0-387-72232-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-387-72231-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-1-4419-4427-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mucosal Immune Defense: Immunoglobulin A
Editors
  • Charlotte S. Kaetzel
Copyright
2007
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-72232-0
DOI
10.1007/978-0-387-72232-0
Hardcover ISBN
978-0-387-72231-3
Softcover ISBN
978-1-4419-4427-6
Edition Number
1
Number of Pages
XVI, 434
Topics

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