Overview
- The studies described in Nucleic Acid Switches and Sensors demonstrate that interesting and useful molecular-scale switches and sensors can be made out of nucleic acids, by both artificial and natural means
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Table of contents (7 chapters)
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Front Matter
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Artificial Nucleic Acid Switches and Sensors
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Front Matter
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Natural Nucleic Acid Switches and Sensors
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Front Matter
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Back Matter
Keywords
About this book
In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.
Authors and Affiliations
Bibliographic Information
Book Title: Nucleic Acid Switches and Sensors
Authors: Scott K. Silverman
DOI: https://doi.org/10.1007/978-0-387-47257-7
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag US 2006
Hardcover ISBN: 978-0-387-37491-8Published: 30 August 2006
Softcover ISBN: 978-1-4419-4248-7Published: 09 October 2011
eBook ISBN: 978-0-387-47257-7Published: 10 June 2010
Edition Number: 1
Number of Pages: IX, 125
Number of Illustrations: 54 b/w illustrations, 3 illustrations in colour
Topics: Human Genetics, Medical Microbiology