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Glycerophospholipids in the Brain

Phospholipases A2 in Neurological Disorders

Authors: Farooqui, Akhlaq A., Horrocks, Lloyd A.

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  • ISBN 978-0-387-49931-4
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  • ISBN 978-1-4939-0210-1
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About this book

Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders
Akhlaq A. Farooqui and Lloyd A. Horrocks

Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders provides a synthesis of material on the metabolism of phospholipids in the brain which has previously only been available in a scattered number of original papers and reviews. Here, the research of over 25 years is collected in one volume from two of the leading researchers in the field— Akhlaq A. Farooqui and Lloyd A. Horrocks

Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders comprehensively describes:

  • metabolism in brain of glycerophospholipids, including those containing a vinyl ether group (plasmalogens)
  • cutting-edge information on the properties and roles of phospholipases A2 in the central nervous system
  • release by phospholipases A2 of second messengers (arachidonic acid, docosahexaenoic acid, and lysophospholipid) from neural membrane phospholipids and their neurochemical effects on brain metabolism and function
  • involvement of phospholipases A2 in neurological and neuropsychiatric disorders, and the use of phospholipase A2 inhibitors for the treatment of diseases associated with altered phospholipid metabolism
  • methods for the assays of phospholipases A2 and their clinical significance

This unique volume will be invaluable not only to those interested in biochemical properties of phospholipases A2, but also their involvement in neurological disorders. Students will benefit from it as a supplement for a range of neuroscience courses. Clinicians will find it invaluable as well for understanding molecular aspects of neurodegeneration in acute neural trauma (stroke) and neurodegenerative diseases (Alzheimer disease) that are mediated by phospholipases A2.

The information in Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders is presented in a lively manner that has never been attempted until now in this specialized format. It will be the essential text for the authoritative research in the field.

About the Authors

Akhlaq A. Farooqui and Lloyd A. Horrocks are leaders in the fields of phospholipid metabolism and phospholipases A2 in brain. They have published cutting edge research on phospholipases A2 and their involvement in neurological disorders in brain tissue. In collaboration with Dr. Yutaka Hirashima, they have discovered a plasmalogen-selective phospholipase A2 in brain. They have also studied phospholipids composition of neural membranes and activities of phospholipases A2 in neural membranes. Lloyd A. Horrocks is the founding editor of Molecular and Chemical Neuropathology and has edited seven books.

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Phospholipid Metabolism in Brain

    Pages 1-34

  • Ether Lipids in Brain

    Pages 35-66

  • Phospholipases A2 in Brain

    Pages 67-92

  • Roles of Phospholipases A2 in Brain

    Pages 93-119

  • Arachidonic Acid and Its Metabolites in Brain

    Pages 121-146

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-0-387-49931-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-387-36602-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4939-0210-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Glycerophospholipids in the Brain
Book Subtitle
Phospholipases A2 in Neurological Disorders
Authors
Copyright
2007
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-49931-4
DOI
10.1007/978-0-387-49931-4
Hardcover ISBN
978-0-387-36602-9
Softcover ISBN
978-1-4939-0210-1
Edition Number
1
Number of Pages
XVI, 394
Topics