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Protein Misfolding, Aggregation and Conformational Diseases

Part B: Molecular Mechanisms of Conformational Diseases

  • Book
  • © 2007

Overview

Editors:
  1. Vladimir N. Uversky

    1. Department of Biochemistry and Molecular Biology, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis
      Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

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    You can also search for this editor in PubMed   Google Scholar

  2. Anthony L. Fink

    1. Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Fills the gap of what has not been discussed in protein review and protocol books
  • Includes supplementary material: sn.pub/extras

Part of the book series: Protein Reviews (PRON, volume 6)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xxv
    Download chapter PDF

  2. Altered Protein Structure and Enhanced Aggregation/Deposition

    1. Front Matter

      Pages 1-1
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    2. Aβ-Protein and Alzheimer’s Disease

      1. The Pathogenesis of Alzheimer’s Disease: General Overview
        • Liana G. Apostolova, Jeffrey L. Cummings
        Pages 3-29
      2. Free Radicals, Metal Ions, and Aβ Aggregation and Neurotoxicity
        • Kevin J. Barnham, Cyril C. Curtain, Ashley I. Bush
        Pages 31-47

    4. β-Synuclein and Parkinson’s Disease

      1. α-Synuclein Aggregation and Parkinson’s Disease
        • Vladimir N. Uversky
        Pages 61-110

    5. Prion Protein and Prion Diseases

      1. Pathogenesis of Prion Diseases
        • Giuseppe Legname, Stephen J. DeArmond, Fred E. Cohen, Stanley B. Prusiner
        Pages 125-146
      2. Mammalian Prion Protein
        • Ilia V. Baskakov
        Pages 147-163
      3. The Yeast Prion Proteins Sup35p and Ure2p
        • Joanna Krzewska, Ronald Melki
        Pages 165-182
      4. Immunoglobulin Light Chain and Systemic Light-Chain Amyloidosis
        • Marina Ramirez-Alvarado, Janelle K. De Stigter, Elizabeth M. Baden, Laura A. Sikkink, Richard W. McLaughlin, Anya L. Taboas
        Pages 183-197
      5. Pancreatic Islet Amyloid and Diabetes
        • Anne Clark, Jenni Moffitt
        Pages 199-216
      6. β2-Microglobulin and Dialysis-Related Amyloidosis
        • Isobel J. Morten, Eric W. Hewitt, Sheena E. Radford
        Pages 217-239
      7. Serum Amyloid A and AA Amyloidosis
        • Zafer Ali-Khan
        Pages 241-256

  3. Point Mutations and Enhanced Protein Deposition

    1. Front Matter

      Pages 257-257
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    2. Transthyretin and the Transthyretin Amyloidoses

      • Joel N. Buxbaum
      Pages 259-283

    3. Human Lysozyme

      • Mireille Dumoulin, Russell J. K. Johnson, Vittorio Bellotti, Christopher M. Dobson
      Pages 285-308

    4. Serpins and the Diversity of Conformational Diseases

      • Robin W. Carrell
      Pages 309-323

  4. Altered Protein Structure and Impaired Function

    1. Front Matter

      Pages 325-325
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    2. Human Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis

      • Ahmad Galaleldeen, P. John Hart
      Pages 327-344
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Keywords

About this book

The second volume continues to fill the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.

Editors and Affiliations

  • Department of Biochemistry and Molecular Biology, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis

    Vladimir N. Uversky

  • Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

    Vladimir N. Uversky

  • Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA

    Anthony L. Fink

Bibliographic Information

  • Book Title: Protein Misfolding, Aggregation and Conformational Diseases

  • Book Subtitle: Part B: Molecular Mechanisms of Conformational Diseases

  • Editors: Vladimir N. Uversky, Anthony L. Fink

  • Series Title: Protein Reviews

  • DOI: https://doi.org/10.1007/978-0-387-36534-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2007

  • Hardcover ISBN: 978-0-387-36529-9Published: 21 February 2007

  • Softcover ISBN: 978-1-4419-4216-6Published: 23 November 2010

  • eBook ISBN: 978-0-387-36534-3Published: 26 May 2007

  • Edition Number: 1

  • Number of Pages: XXVI, 538

  • Number of Illustrations: 98 b/w illustrations, 14 illustrations in colour

  • Topics: Immunology, Cell Biology

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