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Biological Membrane Ion Channels

Dynamics, Structure, and Applications

  • Book
  • © 2007

Overview

Editors:
  1. Shin-Ho Chung

    1. Res. School of Biological Sciences, Australian National University, Canberra, Australia

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  2. Olaf S. Andersen

    1. Weill Medical College Dept. Physiology, Cornell University, New York, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Vikram Krishnamurthy

    1. Dept. of Elect. & Comp. Engi., University of British Columbia, Vancouver, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels
  • Uses schematic diagrams to illustrate important concepts in biophysics
  • Written by leading researchers in the area of ion channel investigations

Part of the book series: Biological and Medical Physics, Biomedical Engineering (BIOMEDICAL)

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Table of contents (19 chapters)

  1. Front Matter

    Pages I-XIV
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  2. Introduction

    1. Front Matter

      Pages I-XIV
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    2. Ion Channels, from Fantasy to Fact in Fifty Years1

      • Peter C. Jordan
      Pages 3-29

  3. Specific Channel Types

    1. Front Matter

      Pages I-XIV
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    2. Gramicidin Channels: Versatile Tools

      • Olaf S. Andersen, Roger E. Koeppe II, Benoît Roux
      Pages 33-80

    3. Voltage-Gated Ion Channels

      • Francisco Bezanilla
      Pages 81-118

    4. Voltage-Gated Potassium Channels

      • Stephen J. Korn, Josef G. Trapani
      Pages 119-170

    5. BKCa-Channel Structure and Function

      • Daniel H. Cox
      Pages 171-218

    6. Voltage-Gated Sodium Channels

      • Dorothy A. Hanck, Harry A. Fozzard
      Pages 219-239

    7. Calcium Channels

      • Ben Corry, Livia Hool
      Pages 241-299

    8. Chloride Transporting CLC Proteins1

      • Michael Pusch
      Pages 301-333

    9. Ligand-Gated Ion Channels: Permeation and Activation1

      • Joseph W. Lynch, Peter H. Barry
      Pages 335-367

    10. Mechanosensitive Channels

      • Boris Martinac
      Pages 369-398

    11. TRP Channels

      • Thomas Voets, Grzegorz Owsianik, Bernd Nilius
      Pages 399-423

    12. Ion Channels in Epithelial Cells

      • Lawrence G. Palmer
      Pages 425-445

  4. Theoretical Approaches

    1. Front Matter

      Pages I-XIV
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    2. Poisson–Nernst–Planck Theory of Ion Permeation Through Biological Channels

      • Rob D. Coalson, Maria G. Kurnikova
      Pages 449-484

    3. A Mesoscopic–Microscopic Perspective on Ion Channel Permeation Energetics: The Semi-Microscopic Approach1

      • Peter C. Jordan
      Pages 485-505

    4. Brownian Dynamics: Simulation for Ion Channel Permeation1

      • Shin-Ho Chung, Vikram Krishnamurthy
      Pages 507-543

    5. Molecular Dynamics Simulation Approaches to K Channels

      • Alessandro Grottesi, Shozeb Haider, Mark S. P. Sansom
      Pages 545-567
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Keywords

About this book

Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.

Key Features

  • Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels
  • Uses schematic diagrams to illustrate important concepts in biophysics
  • Written by leading researchers in the area of ion channel investigations

Editors and Affiliations

  • Res. School of Biological Sciences, Australian National University, Canberra, Australia

    Shin-Ho Chung

  • Weill Medical College Dept. Physiology, Cornell University, New York, USA

    Olaf S. Andersen

  • Dept. of Elect. & Comp. Engi., University of British Columbia, Vancouver, Canada

    Vikram Krishnamurthy

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