Molecular Biology Intelligence Unit
cover

Tight Junctions

Editors: González-Mariscal, Lorenza (Ed.)

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About this book

ight junctions (TJs) are cell-ceil adhesion belts that encircle epithelial and endothelial cells at the limit between the apical and the lateral Tmembrane. These junctions are crucial for the establishment of separate compartments in multicellular organisms and for the exchange of substances between the internal milieu and the external environment. The perception of TJs has changed over the years. From being regarded as static paracellular seals, they have come to be perceived as dynamic structures that adjust their morphol­ ogy and function in response to physiological, pharmacological and pathologi­ cal challenges. The roles that TJs play in epithelial and endothelial cells has also widened, and nowadays this structure is regarded not only as a fence that limits within the membrane, the movement of proteins and lipids between the apical and basolateral membranes, or as a gate that regulates in a size and charge selec­ tive manner the transit of ion and molecules through the paracellular pathway, but also as a structure integrated by molecules that participate in the control of cell proliferation. These observations highlight the importance of understand­ ing TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. This broader perception of TJs is reflected in all the chapters of the book and has been attained thanks to the identification in recent years of a wide array of proteins that constitute TJs in epithelial and endothelial cells as well as in central nervous system myelin.

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Evolution of the Transporting Epithelium Phenotype

    Pages 1-18

    Cereijido, Marcelino (et al.)

  • Occludin, a Constituent of Tight Junctions

    Pages 19-32

    Chen, Yan-Hua (et al.)

  • Tight Junction Channels

    Pages 33-42

    Anderson, James Melvin (et al.)

  • JAM Family Proteins

    Pages 43-53

    Hirabayashi, Susumu (et al.)

  • Cingulin, a Cytoskeleton-Associated Protein of the Tight Junction

    Pages 54-63

    Guillemot, Laurent (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-0-387-36673-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-387-33201-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4419-4115-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tight Junctions
Editors
  • Lorenza González-Mariscal
Series Title
Molecular Biology Intelligence Unit
Copyright
2006
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-36673-9
DOI
10.1007/0-387-36673-3
Hardcover ISBN
978-0-387-33201-7
Softcover ISBN
978-1-4419-4115-2
Series ISSN
1431-0414
Edition Number
1
Number of Pages
XI, 224
Additional Information
Jointly published with Landes Bioscience, Austin, TX, USA
Topics