Molecular Mechanisms of Synaptogenesis

Editors: Dityatev, Alexander, El-Husseini, Alaa (Eds.)

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About this book

Molecular Mechanisms of Synaptogenesis is a compilation of recent exciting findings that summarizes the ever-expanding knowledge of how neuronal contacts develop in the normal brain and how their functions are affected in mental disorders.

In the last decade, advances in molecular and cellular biology, combined with the development of sophisticated fluorescence microscopy tools to visualize synapses in live neurons, have revealed many intriguing and unexpected findings regarding the dynamics of synapse formation. Studies by a number of researchers have identified several critical protein components of synapses and shown the time course of their arrival at the synapse. Several molecules serve to hold the synaptic contacts between nerve cells and regulate their function.

Imbalance in synaptic contact formation and function has been linked to psychiatric disorders such as schizophrenia, autism and mental retardation. The recent advances in basic research, summarized in Molecular Mechanisms of Synaptogenesis, may lay the necessary scientific groundwork to develop treatments targeting synaptogenesis, allowing us to improve the lives of people affected by brain disorders. This book will be an invaluable resource for neurobiologists taking their first steps in the expanding and exciting field of synaptogenesis.

Reviews

From the reviews:

"This volume provides a comprehensive overview and perspectives on the interplay between development, maturity, and disease that is valuable to the newcomer and expert alike. One strength of this volume is that it highlights the breadth of the many experimental systems and approaches that are used to study normal development as well as synaptic defects associated with human diseases. … This volume provides an excellent resource to both established investigators and newcomers to the field." (Ethan G. Hughes and Rita J. Balice-Gordon, Neuron, Vol. 53, 2007)


Table of contents (33 chapters)

Table of contents (33 chapters)
  • Synaptogenesis: When Long-Distance Relations Become Intimate

    Südhof, Thomas C.

    Pages 1-9

  • The Formation of the Vertebrate Neuromuscular Junction: Roles for the Extracellular Matrix in Synaptogenesis

    Burgess, Robert W.

    Pages 13-27

  • Synapse Formation between Identified Molluscan Neurons: A Model System Approach

    Wiersma-Meems, Ryanne (et al.)

    Pages 29-42

  • Development of the Drosophila and C. Elegans Neuromuscular Junctions

    Epps, Heather (et al.)

    Pages 43-65

  • Mechanisms That Regulate Neuronal Protein Clustering at the Synapse

    Hines, Rochelle M. (et al.)

    Pages 67-80

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-0-387-32562-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-0-387-32560-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-1-4419-4090-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Mechanisms of Synaptogenesis
Editors
  • Alexander Dityatev
  • Alaa El-Husseini
Copyright
2006
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-32562-0
DOI
10.1007/b136369
Hardcover ISBN
978-0-387-32560-6
Softcover ISBN
978-1-4419-4090-2
Edition Number
1
Number of Pages
XXVI, 497
Number of Illustrations
59 b/w illustrations, 43 illustrations in colour
Topics