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Transplantation of Neural Tissue into the Spinal Cord

  • Book
  • © 2006

Overview

Authors:
  1. Antal Nógrádi

    1. Department of Ophthalmology, University of Szeged, Albert Szent-Györgyi Medical Center, Szeged, Hungary

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  • Designed to bridge the gap between basic researchers and clinical practitioners in thie field
  • Reflects the present state of the art of the subject, where there is a great body of morphological, immunocytochemical and molecular information available as to the events that occur during graft-host interactions, but not enough literature

Part of the book series: Neuroscience Intelligence Unit (NIU.LANDES)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xi
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  2. Anatomy and Physiology of the Spinal Cord

    • Antal Nógrádi, Gerta Vrbová
    Pages 1-23

  3. Recovery of Function After Spinal Cord Injury

    • Gavin Clowry, Urszula Slawinska
    Pages 24-51

  4. Recovery of Lost Spinal Cord Function by Facilitating the Spinal Cord Circuits Below the Lesion

    • Urszula Slawinska
    Pages 52-66

  5. Encouraging Regeneration of Host Neurons:

    • Antal Nógrádi
    Pages 67-88

  6. Encouraging Regeneration of Host Neurons:

    • Gerta Vrbová
    Pages 89-109

  7. Replacement of Specific Neuronal Populations in the Spinal Cord

    • Antal Nógrádi
    Pages 110-122

  8. Replacement of Specific Populations of Cells

    • Antal Nógrádi
    Pages 123-144

  9. Conclusion

    Pages 145-146

  10. Back Matter

    Pages 147-150
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Keywords

About this book

The book gives an account of results obtained from experiments where grafts of neuronal, glial and other tissues as well as artificial materials were placed into the spinal cord. It attempts to evaluate the contributions made by these studies to our understanding of basic neurobiologies questions. These include factors that regulate neuronal growth during development as well as regenera­ tion following injury to the nervous system. The model of neural transplanta­ tion is also useful for the study of cell-to-cell interactions, and this applies to interactions between glial cells and neurones, between various populations of neuronal cells and finally between axons and skeletal muscle fibres. The mecha­ nisms involved in the establishment of specific synaptic connections between neurones can also be investigated in this experimental paradigm. Important in­ formation regarding this issue was also obtained on systems other than the spinal cord, i. e. the cerebellum, hippocampus and striatum. Although such in­ formation of precise connections between the host and the grafted embryonic tissue is still lacking in the spinal cord, there is much information on the re­ sponse of the host nervous system to the grafted embryonic tissue, and that of the graft to its new host environment. It appears that embryonic grafts are able to induce repair processes follow­ ing injury to the nervous system.

Reviews

From the reviews of the second edition:

"This book is organized into 5 major chapters assessing spinal cord injury as well as replacement strategies targeting different cellular populations. … will be of teaching value to students in the field of neuroanatomy and spinal cord injury. … Images throughout the book are easy to read, with appropriate figure legends to explain the major conclusions … . I would recommend this book to audiences interested in spinal cord injury and the discussion of novel strategies directed toward repairing the injured cord." (American Journal of Neuroradiology, May, 2007)

Authors and Affiliations

  • Department of Ophthalmology, University of Szeged, Albert Szent-Györgyi Medical Center, Szeged, Hungary

    Antal Nógrádi

Bibliographic Information

  • Book Title: Transplantation of Neural Tissue into the Spinal Cord

  • Authors: Antal Nógrádi

  • Series Title: Neuroscience Intelligence Unit

  • DOI: https://doi.org/10.1007/0-387-32633-2

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2006

  • Hardcover ISBN: 978-0-387-26355-7Published: 13 January 2006

  • Softcover ISBN: 978-1-4899-9225-3Published: 06 December 2014

  • eBook ISBN: 978-0-387-32633-7Published: 30 June 2007

  • Series ISSN: 1431-0406

  • Edition Number: 2

  • Number of Pages: XI, 150

  • Additional Information: Jointly published with R.G.Landes Biomedical Publishers, Georgetown, USA

  • Topics: Neurosciences, Neurobiology, Neurology, Transplant Surgery

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