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- About this book
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Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
- Table of contents (17 chapters)
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How the Hedgehog Outfoxed the Crab
Pages 1-22
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The Patched Receptor
Pages 23-33
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Making a Morphogenetic Gradient
Pages 34-40
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Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signaling
Pages 41-52
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Mode of PTCH1/Ptch1-Associated Tumor Formation
Pages 53-62
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Table of contents (17 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Hedgehog-Gli Signaling in Human Disease
- Editors
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- Ariel Ruiz i Altaba
- Series Title
- Molecular Biology Intelligence Unit
- Copyright
- 2006
- Publisher
- Springer US
- Copyright Holder
- Springer-Verlag US
- eBook ISBN
- 978-0-387-33777-7
- DOI
- 10.1007/0-387-33777-6
- Hardcover ISBN
- 978-0-387-25784-6
- Softcover ISBN
- 978-1-4899-8976-5
- Series ISSN
- 1431-0414
- Edition Number
- 1
- Number of Pages
- XIII, 228
- Additional Information
- Jointly published with Landes Bioscience, Austin, TX, USA
- Topics
