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Proteomics and Protein-Protein Interactions

Biology, Chemistry, Bioinformatics, and Drug Design

  • Book
  • © 2005

Overview

Editors:
  1. Gabriel Waksman

    1. Institute of Structural Molecular Biology, Birkbeck and University College London, UK

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  • The only book that gives such a broad overview of protein-protein interactions and their importance
  • Provides a complete view of the field by addressing issues on protein-protein interactions from their discovery (2 hybrid and mass spectrometry), to their biochemical and biophysical characterization, to their bioinformatics treatment, to their exploration as drug targets
  • In the age of proteomics, i.e. large scale and high throughput mode of discovery, the book not only provides insights into the new techonology, its scope, and its limits, but also connects to the more traditional ways of looking into the issue
  • One theme permeating all chapters in the book is the use of structural biology as a common denominator to study protein-protein interactions; this is unique to this book. Due to the resulting rich color illustrations, the book will be printed in full color throughout
  • Each chapter has been written by leading experts in their respective field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Protein Reviews (PRON, volume 3)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Introduction: Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design

    • Gabriel Waksman, Clare Sansom
    Pages 1-18

  3. Yeast Two-Hybrid Protein-Protein Interaction Networks

    • Daniel Auerbach, Igor Stagljar
    Pages 19-31

  4. The Use of Mass Spectrometry in Studying Protein-Protein Interaction

    • Yi Wang, Parvin Yazdi, Jun Qin
    Pages 33-48

  5. Molecular Recognition in the Immune System

    • Eric J. Sundberg, Roy A. Mariuzza
    Pages 49-87

  6. Computational Methods for Predicting Protein-Protein Interactions

    • A. Walker-Taylor, D. T. Jones
    Pages 89-114

  7. Protein-Protein Docking Methods

    • Garland R. Marshall, Ilya A. Vakser
    Pages 115-146

  8. Thermochemistry of Binary and Ternary Protein Interactions Measured by Titration Calorimetry: Complex Formation of CD4, HIV gp120, and Anti-gp120

    • Michael L. Doyle, Preston Hensley
    Pages 147-163

  9. Protein-Protein Recognition in Phosphotyrosine-Mediated Intracellular Signaling

    • John E. Ladbury
    Pages 165-184

  10. Competitive Binding of Proline-Rich Sequences by SH3, WW, and Other Functionally Related Protein Domains

    • Marius Sudol, Mark T. Bedford
    Pages 185-201

  11. The Structure and Molecular Interactions of the Bromodomain

    • Kelley S. Yan, Ming-Ming Zhou
    Pages 203-218

  12. SMART Drug Design: Novel Phosphopeptide and ATP Mimetic-Based Small Molecule Inhibitors of the Oncogenic Protein Kinase pp60src (Src)

    • T. K. Sawyer, R. S. Bohacek, W. C. Shakespeare, C. A. Metcalf III, Y. Wang, R. Sundaramoorthi et al.
    Pages 219-253

  13. Disrupting Protein-Protein Interaction: Therapeutic Tools Against Brain Damage

    • Michelle Aarts, Michael Tymianski
    Pages 255-289

  14. A Thermodynamic Guide to Affinity Optimization of Drug Candidates

    • Ernesto Freire
    Pages 291-307

  15. Back Matter

    Pages 309-323
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Keywords

About this book

Gabriel Waksman Institute of Structural Molecular Biology, Birkbeck and University College London, Malet Street, London WC1E 7HX, United Kingdom Address for correspondence: Professor Gabriel Waksman Institute of Structural Molecular Biology Birkbeck and University College London Malet Street London WC1E 7H United Kingdom Email: g. waksman@bbk. ac. uk and g. waksman@ucl. ac. uk Phone: (+44) (0) 207 631 6833 Fax: (+44) (0) 207 631 6833 URL: http://people. cryst. bbk. ac. uk/?ubcg54a Gabriel Waksman is Professor of Structural Molecular Biology at the Institute of Structural Molecular Biology at UCL/Birkbeck, of which he is also the director. Before joining the faculty of UCL and Birkbeck, he was the Roy and Diana Vagelos Professor of Biochemistry and Molecular Biophysics at the Washington University School of Medicine in St Louis (USA). The rapidly evolving ?eld of protein science has now come to realize the ubiquity and importance of protein–protein interactions. It had been known for some time that proteins may interact with each other to form functional complexes, but it was thought to be the property of only a handful of key proteins. However, with the advent of hi- throughput proteomics to monitor protein–protein interactions at an organism level, we can now safely state that protein–protein interactions are the norm and not the exception.

Reviews

 

"While there are several books on Protemics on the market currently, Protemics and Protein-Protein Interactions is unique in that it focuses on technical issues and on the protein interactome itself. This very important and active research area is brought together by some of the leaders in the field to present a coherent entry point into a field that appeals to many. This will be a valuable and long-lived volume. It will certainly make a timely addition to any library or book collection."

(Mark A. Lemmon, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania)

Editors and Affiliations

  • Institute of Structural Molecular Biology, Birkbeck and University College London, UK

    Gabriel Waksman

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