Subcellular Biochemistry

Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta

Editors: Harris, J. Robin, Fahrenholz, Falk (Eds.)

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About this book

This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics:- transgenic mouse models of AD; the enzymology of amyloid-ß production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-ß oligomers and fibrils, the role of cholesterol in their formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-ß on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the ß-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-ß phosphorylation receives detailed attention.

Overall, the book contains a broad range of current information on cellular, biochemical and structural aspects of amyloid-ß, of direct relevance to Alzheimer’s disease.

 

Table of contents (20 chapters)

Table of contents (20 chapters)
  • The Contribution of Microscopy to the Study of Alzheimer’s Disease, Amyloid Plaques and Aβ Fibrillogenesis

    Harris, J. Robin

    Pages 1-44

  • Transgenic Mouse Models for APP Processing and Alzheimer’s Disease: Early and Late Defects

    Dooren, Tom (et al.)

    Pages 45-63

  • Oxidative stress in Alzheimer’s Disease: Implications for Prevention and Therapy

    Behl, Christian

    Pages 65-78

  • β-Secretase, APP and Aβ in Alzheimer’s Disease

    Vassar, Robert

    Pages 79-103

  • The Non-Amyloidogenic Pathway: Structure and Function of α-Secretases

    Kojro, Elżbieta (et al.)

    Pages 105-127

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-0-387-23226-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-0-387-23225-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-1-4614-9841-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta
Editors
  • J. Robin Harris
  • Falk Fahrenholz
Series Title
Subcellular Biochemistry
Series Volume
38
Copyright
2005
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-23226-3
DOI
10.1007/b100942
Hardcover ISBN
978-0-387-23225-6
Softcover ISBN
978-1-4614-9841-4
Series ISSN
0306-0225
Edition Number
1
Number of Pages
XVII, 409
Topics