Skip to main content
SpringerLink
Log in
Book cover

Biochemistry and Molecular Biology of Antimicrobial Drug Action

  • Textbook
  • © 2005

Overview

Authors:
  1. T. J. Franklin

    1. AstraZeneca Alderley Park, Macclesfield Cheshire, England

    View author publications

    You can also search for this author in PubMed   Google Scholar

  2. G. A. Snow

    1. AstraZeneca Alderley Park, Macclesfield Cheshire, England

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • Useful to medical and biological sciences students in the fields of pharmacology, molecular biology, microbiology, biochemistry and chemotherapeutics
  • An important text for those involved in research into drug action and development, whether in the pharmaceutical industry or academia
  • Includes supplementary material: sn.pub/extras

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (9 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. The development of antimicrobial agents, past, present and future

    Pages 1-15

  3. Vulnerable shields—the cell walls of bacteria and fungi

    Pages 17-45

  4. Antimicrobial agents and cell membranes

    Pages 47-64

  5. Inhibitors of nucleic acid biosynthesis

    Pages 65-83

  6. Inhibitors of protein biosynthesis

    Pages 85-105

  7. Antimicrobial drugs with other modes of action

    Pages 107-120

  8. Attack and defense: drug transport across cell walls and membranes

    Pages 121-134

  9. The genetic basis of resistance to antimicrobial drugs

    Pages 135-148

  10. Biochemical mechanisms of resistance to antimicrobial drugs

    Pages 149-174

  11. Back Matter

    Pages 175-182
    Download chapter PDF
Back to top

Keywords

About this book

Preface to the sixth edition x 1 THE DEVELOPMENT OF ANTIMICROBIAL AGENTS, PAST, PRESENT AND FUTURE 1 1. 1 The social and economic importance of antimicrobial agents 1 1. 2 All outhne of the historical development of antimicrobial agents 2 1. 3 Reasons for studying the biochemistry and molecular biology of antimicrobial compounds 9 1. 4 Uncovering the molecular basis of antimicrobial action iO 1. 5 Current trends in the discovery of antimicrobial drugs 14 1. 6 . Scope and layout of the book 15 2 VULNERABLE SHIELDS—THE CELL WALLS OF BACTERIA AND FUNGI 17 2. 1 Functions of the ceU wall 17 2. 2 . Structure of the bacterial wall 17 2. 3 Structure and biosynthesis of peptidoglycan 22 2. 4 Antibiotics that inhibit peptidoglycan biosynthesis 29 2. 5 Drugs that interfere with the biosynthesis of the cell wall of mycobacteria 39 2. 6 The fungal cell wall as a target for antifungal drugs 41 3 ANTIMICROBIAL AGENTS AND CELL MEMBRANES 47 3. 1 Microbe killers: antiseptics and disinfectants 47 3. 2 Cationic peptide antibiotics 52 3. 3 lonophoric antibiotics 54 3. 4 Antifungal agents that interfere with the function and biosynthesis of membrane sterols 59 4 INHIBITORS OF NUCLEIC ACID BIOSYNTHESIS 65 4. 1 Compounds affecting the biosynthesis and utilization of nucleotide precursors 66 4. 2 Nucleoside analogues 70 4. 3 Inhibitors of the reverse transcriptase of the human immunodeficiency virus 72 4. 4 Antibacterial inhibitors of topoisomerases 75 4.

Reviews

From the reviews of the sixth edition:

"This sixth edition builds on the successful formula of its predecessors with an accessible small format, clear diagrams and illustrations, key antibiotic structures and an engaging explanatory text. … the great strength ... is that it has managed to convey the essentials of the topic without … expanding in girth at each edition. … this book remains the first port of call for those requiring an overview of the topic or seeking a starting point for more in-depth information on an unfamiliar antimicrobial." (Jonathan H Cove, British Toxicology Society Newsletter, Winter, 2005)

Authors and Affiliations

  • AstraZeneca Alderley Park, Macclesfield Cheshire, England

    T. J. Franklin, G. A. Snow

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation