Buy this book
- About this book
-
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer.
Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology.
To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
About the Author:
Martin Beckerman, Ph.D. is Senior Scientist at the Center forMartin Beckerman, PhD, is a senior research scientist at the Department of Energy/National Nuclear Security Administration’s Y-12 National Security Complex in Oak Ridge, TN. Prior to assuming his current position at the Y-12 NSC, Dr. Beckerman held teaching and research positions at the Weizmann Institute of Science, the University of Rochester, the Massachusetts Institute of Technology, the University of Tennessee and the Oak Ridge National Laboratory. He has authored over 130 publications and has been included in 1400 citations.
- About the authors
-
Martin Beckerman, Ph.D. is Senior Scientist at the Department of Energy/National Nuclear Security Administration’s Y-12 National Security Complex in Oak Ridge, TN. Prior to assuming his current position at the Y-12 NSC, Dr. Beckerman held teaching and research positions at the Weizmann Institute of Science, the University of Rochester, the Massachusetts Institute of Technology, the University of Tennessee and the Oak Ridge National Laboratory. He has over 130 publications, 1400 citations, and is the author of a previously published book entitled Adaptive Cooperative Systems.
- Table of contents (21 chapters)
-
-
Introduction
Pages 1-19
-
The Control Layer
Pages 21-43
-
Exploring Protein Structure and Function
Pages 45-69
-
Macromolecular Forces
Pages 71-87
-
Protein Folding and Binding
Pages 89-109
-
Table of contents (21 chapters)
- Download Preface 1 PDF (34.4 KB)
- Download Sample pages 1 PDF (281 KB)
- Download Table of contents PDF (78.3 KB)
Recommended for you
Bibliographic Information
- Bibliographic Information
-
- Book Title
- Molecular and Cellular Signaling
- Authors
-
- Martin Beckerman
- Series Title
- Biological and Medical Physics, Biomedical Engineering
- Copyright
- 2005
- Publisher
- Springer-Verlag New York
- Copyright Holder
- Springer-Verlag New York
- Distribution Rights
- Distribution rights for India: CBS Publishers, New Delhi, India
- eBook ISBN
- 978-0-387-26015-0
- DOI
- 10.1007/b136493
- Hardcover ISBN
- 978-0-387-22130-4
- Softcover ISBN
- 978-1-4419-1966-3
- Series ISSN
- 1618-7210
- Edition Number
- 1
- Number of Pages
- XXXIV, 582
- Number of Illustrations
- 227 b/w illustrations
- Topics
