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Retroviruses and Insights into Cancer

Editors: Dudley, Jaquelin (Ed.)

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  • Provides current research in a specific field where most publications are at least ten years old
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-0-387-09581-3
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Hardcover $249.99
price for USA in USD
  • ISBN 978-0-387-09580-6
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  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
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  • ISBN 978-1-4899-8143-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Retroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors. Studies of retrovirus-induced tumors have led to our understanding of many crucial concepts in cell and cancer biology, including the discoveries of reverse transcriptase, viral oncogenes, cellular proto-oncogenes and signal transduction pathways. This monograph provides an intriguing set of chapters on the many facets of retroviral involvement in cancers arising in a variety of organisms from fish to humans. Each chapter is written by experts in the field and relates recent work to previous experimental data. Retroviruses use many different mechanisms to induce cancers, ranging from activation of microRNAs, inactivation of tumor suppressor genes, activation or modifications of proto-oncogenes, as well as expression of viral proteins that manipulate cell signaling and the immune system. In recent years, retroviruses have been used as tools, not only for the characterization of cellular pathways, but also as vectors to deliver therapeutic or engineered genes. This knowledge is all the more startling due to the revelation that nearly 10% of the human genome consists of endogenous retroviruses, including many that are transcriptionally active. The emergence of new endogenous retroviruses causing lethal leukemias in koalas and, potentially, prostate cancer in humans ensures that the unique interactions of these viruses with their hosts will continue to fascinate and illuminate us.

Table of contents (11 chapters)

Table of contents (11 chapters)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-0-387-09581-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-0-387-09580-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4899-8143-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Retroviruses and Insights into Cancer
Editors
  • Jaquelin Dudley
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-0-387-09581-3
DOI
10.1007/978-0-387-09581-3
Hardcover ISBN
978-0-387-09580-6
Softcover ISBN
978-1-4899-8143-1
Edition Number
1
Number of Pages
XII, 363
Topics