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Medical Intelligence Unit

DNA Methylation and Cancer Therapy

Authors: Szyf, Moshe

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About this book

NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo­ Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me­ thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat­ terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac­ tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.

Table of contents (17 chapters)

Table of contents (17 chapters)
  • DNA Methylation

    Pages 1-12

    Razin, Aharon

  • Epigenetic Mechanisms of Gene Regulation

    Pages 13-30

    Robertson, Keith D.

  • DNA Hypo- vs. Hypermethylation in Cancer

    Pages 31-41

    Ehrlich, Melanie (et al.)

  • DNA Methylation in Urological Cancers

    Pages 42-58

    Schulz, Wolfgang A. (et al.)

  • DNA Methylation in Colorectal Cancer

    Pages 59-68

    Jass, Jeremy R. (et al.)

Buy this book

eBook $189.00
price for USA in USD
  • ISBN 978-0-387-27443-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
Softcover $249.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
DNA Methylation and Cancer Therapy
Authors
Series Title
Medical Intelligence Unit
Copyright
2005
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-27443-0
DOI
10.1007/b139080
Hardcover ISBN
978-0-306-47848-2
Softcover ISBN
978-1-4419-3416-1
Edition Number
1
Number of Pages
XV, 239
Number of Illustrations
67 b/w illustrations, 2 illustrations in colour
Topics