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Advances in Experimental Medicine and Biology

Retinal Degenerations

Mechanisms and Experimental Therapy

Editors: LaVail, Matthew M, Hollyfield, Joe G., Anderson, Robert E. (Eds.)

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eBook $149.00
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  • ISBN 978-1-4615-0067-4
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Hardcover $319.00
price for USA in USD
  • ISBN 978-0-306-47781-2
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Softcover $199.00
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  • ISBN 978-1-4613-4909-9
  • Free shipping for individuals worldwide
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About this book

The topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.
Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early or congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.

Table of contents (49 chapters)

  • Identification of the RP1 and RP10 (IMPDH1) Genes Causing Autosomal Dominant RP

    Daiger, Stephen P. (et al.)

    Pages 1-11

  • On the Role of IMPDH1 in Retinal Degeneration

    Kennan, Avril (et al.)

    Pages 13-18

  • An Integrated Genetic Approach to Identify Candidate Genes for Human Chromosome 6q-Linked Retinal Disorders

    Lagali, Pamela S. (et al.)

    Pages 19-28

  • Mouse Genetic Approaches to Access Pathways Important in Retinal Function

    Nishina, Patsy M. (et al.)

    Pages 29-34

  • Retinal Degenerative Disorders in Southern Africa: A Molecular Genetic Approach

    Ramesar, R.S. (et al.)

    Pages 35-40

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-4615-0067-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $319.00
price for USA in USD
  • ISBN 978-0-306-47781-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.00
price for USA in USD
  • ISBN 978-1-4613-4909-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Retinal Degenerations
Book Subtitle
Mechanisms and Experimental Therapy
Editors
  • Matthew M LaVail
  • Joe G. Hollyfield
  • Robert E. Anderson
Series Title
Advances in Experimental Medicine and Biology
Series Volume
533
Copyright
2003
Publisher
Springer US
Copyright Holder
Kluwer Academic/Plenum Publishers, New York
eBook ISBN
978-1-4615-0067-4
DOI
10.1007/978-1-4615-0067-4
Hardcover ISBN
978-0-306-47781-2
Softcover ISBN
978-1-4613-4909-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVI, 467
Topics