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Retinal Degenerations

Mechanisms and Experimental Therapy

  • Conference proceedings
  • © 2003

Overview

Editors:
  1. Matthew M. LaVail

    1. Beckman Vision Center, University of California, San Francisco, USA

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  2. Joe G. Hollyfield

    1. Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Robert E. Anderson

    1. Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 533)

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Table of contents (57 papers)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Identification of the RP1 and RP10 (IMPDH1) Genes Causing Autosomal Dominant RP

    • Stephen P. Daiger, Lori S. Sullivan, Sara J. Bowne, Avril Kennan, Peter Humphries, David G. Birch et al.
    Pages 1-11

  3. On the Role of IMPDH1 in Retinal Degeneration

    • Avril Kennan, Aileen Aherne, Sara J. Bowne, Stephen P. Daiger, G. Jane Farrar, Paul F. Kenna et al.
    Pages 13-18

  4. An Integrated Genetic Approach to Identify Candidate Genes for Human Chromosome 6q-Linked Retinal Disorders

    • Pamela S. Lagali, Radha Ayyagari, Paul W. Wong
    Pages 19-28

  5. Mouse Genetic Approaches to Access Pathways Important in Retinal Function

    • Patsy M. Nishina, Jürgen K. Naggert
    Pages 29-34

  6. Retinal Degenerative Disorders in Southern Africa: A Molecular Genetic Approach

    • R.S. Ramesar, L. Roberts, G. Rebello, R. Goliath, A. Vorster, A. September et al.
    Pages 35-40

  7. Comparing Rod and Cone Function with Fundus Autofluorescence Images in Retinitis Pigmentosa

    • Anthony G. Robson, Catherine Egan, Graham E. Holder, Alan C. Bird, Fred W. Fitzke
    Pages 41-47

  8. A Modified Protocol for the Assessment of Visual Function in Patients with Retinitis Pigmentosa

    • N. Lodha, C. A. Westall, M. Brent, M. Abdolell, E. Héon
    Pages 49-57

  9. Prenatal Human Ocular Degeneration Occurs in Leber’s Congenital Amaurosis

    • Fernanda B. O. Porto, Isabelle Perrault, David Hicks, Jean-Michel Rozet, Noëlle Hanoteau, Sylvain Hanein et al.
    Pages 59-68

  10. Leber Congenital Amaurosis — Genotyping Required for Possible Inclusion in a Clinical Trial

    • Isabelle Perrault, Sylvie Gerber, Sylvain Hanein, Serge Picaud, Jean-Michel Rozet, Jean-Louis Dufier et al.
    Pages 69-77

  11. Treatment of Cystoid Macular Edema Related to Retinitis Pigmentosa with Intravitreal Triamcinolone Acetonide: Case Report

    • Juliana M. F. Sallum, Michel E. Farah, Vinicius S. Saraiva
    Pages 79-81

  12. Proteomic Approaches to Understanding Age-Related Macular Degeneration

    • Joe G. Hollyfield, Robert G. Salomon, John W. Crabb
    Pages 83-89

  13. Progressive Pathways in Age-Related Macular Degeneration

    • Kimberly A. Howes, Jeanne M. Frederick, Alexander Marks, Wolfgang Baehr
    Pages 91-96

  14. Tissue Inhibitor of Metalloproteinases-3 and Sorsby Fundus Dystrophy

    • Jian Hua Qi, Quteba Ebrahem, Bela Anand-Apte
    Pages 97-105

  15. Investigations of RPE Cells of Choriodal Neovascular Membranes from Patients with Age-Related Macula Degeneration

    • Rita Rosenthal, Olaf Strauß
    Pages 107-113

  16. Retinal and Choroidal Alterations Following Photodynamic Therapy

    • Yusuf K. Durlu
    Pages 115-122

  17. Usher Syndrome: Correlation between Visual Field Size and Maximal ERG Response B-Wave Amplitude

    • Alessandro Iannaccone
    Pages 123-131

  18. The Cellular Function of the Usher Gene Product Myosin VIIa is Specified by Its Ligands

    • Uwe Wolfrum
    Pages 133-142

  19. Mouse Models for Usher Syndrome 1b

    • Concepcion Lillo, Junko Kitamoto, Xinran Liu, Elizabeth Quint, Karen P. Steel, David S. Williams
    Pages 143-150

  20. Screen for Usher Syndrome 1b Mutations in the Ovine Myosin VIIa Gene

    • Tania Slatter, Sassan M. Azarian, Scott Tebbutt, Marion Maw, David S. Williams
    Pages 151-155
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Keywords

About this book

The topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.
Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early or congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.

Editors and Affiliations

  • Beckman Vision Center, University of California, San Francisco, USA

    Matthew M. LaVail

  • Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, USA

    Joe G. Hollyfield

  • Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, USA

    Robert E. Anderson

Bibliographic Information

  • Book Title: Retinal Degenerations

  • Book Subtitle: Mechanisms and Experimental Therapy

  • Editors: Matthew M. LaVail, Joe G. Hollyfield, Robert E. Anderson

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-0067-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2003

  • Hardcover ISBN: 978-0-306-47781-2Published: 31 October 2003

  • Softcover ISBN: 978-1-4613-4909-9Published: 11 February 2013

  • eBook ISBN: 978-1-4615-0067-4Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVI, 467

  • Topics: Ophthalmology, Neurology, Neurosciences, Epidemiology, Tree Biology

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