Heme Oxygenase in Biology and Medicine

Editors: Abraham, Nader G. (Ed.)

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About this book

Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter­ acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod­ ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis­ ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research.

Table of contents (43 chapters)

Table of contents (43 chapters)
  • Development of Heme Oxygenase Inhibitors for the Prevention of Severe Jaundice in Infants

    Pages 3-17

    Kappas, Attallah

  • Carbon Monoxide

    Pages 19-29

    Ryter, Stefan W. (et al.)

  • Correlation of the Altered Vascular Effects of Carbon Monoxide and the Cardiovascular Complications of Diabetes

    Pages 31-41

    Wang, Rui (et al.)

  • Endogenous Carbon Monoxide has Protective Roles in Neointimal Development Elicited by Arterial Injury

    Pages 43-54

    Morita, Toshisuke, MD, Ph.D. (et al.)

  • End Tidal Breath Carbon Monoxide (ETCO) Levels in Pregnant Women

    Pages 55-65

    Seidman, Daniel S. (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-4615-0741-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA in USD
  • ISBN 978-0-306-47264-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4613-5219-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Heme Oxygenase in Biology and Medicine
Editors
  • Nader G. Abraham
Copyright
2002
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-0741-3
DOI
10.1007/978-1-4615-0741-3
Hardcover ISBN
978-0-306-47264-0
Softcover ISBN
978-1-4613-5219-8
Edition Number
1
Number of Pages
XIX, 515
Topics