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Ectopeptidases

CD13/Aminopeptidase N and CD26/Dipeptidylpeptidase IV in Medicine and Biology

Editors: Langner, Jürgen, Ansorge, Siegfried (Eds.)

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About this book

The idea to compile recent results on the ectoenzymes aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 arose from the great interest given by readers world-wide to the two proceedings volumes edited by us in 1997 and 2000 (Ansorge and Langner, 1997; Langner and Ansorge, 2000). These volumes contained the presentations at two symposia held in Magdeburg (Germany) in 1996 and 1999 under the title "Cellular peptidases in immune functions and diseases", which was also the name of the Sonderforschungsbereich in Magdeburg, sponsored by the Deutsche Forschungsgemeinschaft between 1995 and 2001. Our groups in Magdeburg and Halle during the last two decades have provided results on these two enzymes in cells of the hematopoietic system that justify a review in an edited monograph like the present one (see the reviews by Kahne et at. , 1999; Lendeckel et at. ,1999; Riemann et at. , 1999). There are, however, many other groups in Europe, US and Japan which made important contributions to this field and particularly in topics improving the understanding of physiological and pathophysiological roles ofAPN/CD13 and DPIV/CD26. Therefore we decided to invite some of them to contribute reviews of their results to this book. Having worked for about 40 years in the field of proteolysis, for both of us to see the development of activities and knowledge from protein chemistry and enzymology to physiology and pathophysiology and even to therapy is very stimulating and fascinating. Of course, this development also reflects the dramatic improvement and refinement of methods.

Table of contents (12 chapters)

Table of contents (12 chapters)
  • Detection of the Activity of the Ectopeptidases DPIV and APN Using Sensitive Fluorogenic Substrates

    Pages 1-24

    Mrestani-Klaus, Carmen (et al.)

  • CD13/APN in Hematopoetic Cells — Expression, Function, Regulation, and Clinical Aspects

    Pages 25-49

    Lendeckel, Uwe (et al.)

  • New Selective Aminopeptidase N Inhibitors as Potential Therapeutics

    Pages 51-94

    Fournié-Zaluski, Marie-Claude (et al.)

  • Physiological Roles of Ectoenzymes Indicated by the Use of Aminopeptidase Inhibitors

    Pages 95-122

    Abe, Fuminori (et al.)

  • CD13/APN as a Target for Inhibiting Tumor Angiogenesis

    Pages 123-139

    Bhagwat, Shripad V. (et al.)

Buy this book

eBook $99.00
price for USA in USD (gross)
  • ISBN 978-1-4615-0619-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA in USD
  • ISBN 978-0-306-46788-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $129.00
price for USA in USD
  • ISBN 978-1-4613-5161-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Ectopeptidases
Book Subtitle
CD13/Aminopeptidase N and CD26/Dipeptidylpeptidase IV in Medicine and Biology
Editors
  • Jürgen Langner
  • Siegfried Ansorge
Copyright
2002
Publisher
Springer US
Copyright Holder
Kluwer Academic / Plenum Publishers, New York
eBook ISBN
978-1-4615-0619-5
DOI
10.1007/978-1-4615-0619-5
Hardcover ISBN
978-0-306-46788-2
Softcover ISBN
978-1-4613-5161-0
Edition Number
1
Number of Pages
XVI, 310
Topics

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