Phospholipid Metabolism in Apoptosis
Editors: Quinn, Peter J., Kagan, Valerian E. (Eds.)
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- About this book
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The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. The number of publications on the topic has increased from nothing in the early 1980s to more than 10,000 papers annually today. It is now well recognized that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The idea that life requires death seems somewhat paradoxical, but cell suicide is essential for an animal to survive. For example, without selective destruction of “non-self” T cells, an animal would lack immunity. Similarly, meaningful neural connections in the brain are whittled from a mass of cells. Further, developmental cell remodeling during tissue maturation involves programmed cell death as the major mechanism for functional and structural safe transition of undifferentiated cells to more specialized counterparts. Apoptosis research, with roots in biochemistry, developmental and cell biology, genetics, and immunology, embraces this long-ignored natural law. Failure to properly regulate apoptosis can have catastrophic consequences. Cancer and many diseases (AIDS, Alzheimer’s disease, Parkinson’s disease, heart attack, stroke, etc. ) are thought to arise from deregulation of apoptosis. As apoptosis emerges as a key biological regulatory mechanism, it has become harder and harder to keep up with new developments in this field.
- Table of contents (16 chapters)
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Lipid Metabolism and Release of Cytochrome c from Mitochondria
Pages 1-17
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Interaction Between Cytochrome c and Oxidized Mitochondrial Lipids
Pages 19-37
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Plasma Membrane Phospholipid Asymmetry
Pages 39-60
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Apoptosis by Phosphatidylserine in Mammalian Cells
Pages 61-77
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Phosphatidylserine Peroxidation During Apoptosis
Pages 79-96
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Table of contents (16 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Phospholipid Metabolism in Apoptosis
- Editors
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- Peter J. Quinn
- Valerian E. Kagan
- Series Title
- Subcellular Biochemistry
- Series Volume
- 36
- Copyright
- 2002
- Publisher
- Springer US
- Copyright Holder
- Springer Science+Business Media New York
- eBook ISBN
- 978-0-306-47931-1
- DOI
- 10.1007/b105359
- Hardcover ISBN
- 978-0-306-46782-0
- Softcover ISBN
- 978-1-4757-8216-5
- Series ISSN
- 0306-0225
- Edition Number
- 1
- Number of Pages
- XVI, 340
- Number of Illustrations
- 30 b/w illustrations
- Topics
