Mitochondria in Pathogenesis

1. Front Matter

   Pages i-xxiii

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2. Evaluation of Mitochondrial Function in Intact Cells

   1. Front Matter

      Pages 1-1

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   2. Flow Cytometric Analysis of Mitochondrial Function

      • Hagai Rottenberg

      Pages 3-20

   3. Confocal Microscopy of Mitochondrial Function in Living Cells

      • John J. Lemasters, Ting Qian, Donna R. Trollinger, Wayne E. Cascio, Hisayuki Ohata, Anna-Liisa Nieminen

      Pages 21-49

3. Mitochondrial Disease and Aging

   1. Front Matter

      Pages 51-51

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   2. Primary Disorders of Mitochondrial DNA and the Pathophysiology of mtDNA-Related Disorders

      • Eric A. Schon, Salvatore DiMauro

      Pages 53-80

   3. Transmission and Segregation of Mammalian Mitochondrial DNA

      • Eric A. Shoubridge

      Pages 81-93

   4. Cardiac Reperfusion Injury: Aging, Lipid Peroxidation, and Mitochondrial Function

      • Luke I. Szweda, David T. Lucas, Kenneth M. Humphries, Pamela A. Szweda

      Pages 95-111

4. Mitochondrial Ion Homeostasis and Necrotic Cell Death

   1. Front Matter

      Pages 113-113

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   2. Ca2+-Induced Transition in Mitochondria: A Cellular Catastrophe?

      • Robert A. Haworth, Douglas R. Hunter

      Pages 115-124

   3. Physiology of the Permeability Transition Pore

      • Mario Zoratti, Francesco Tombola

      Pages 125-152

   4. Control of Mitochondrial Metabolism by Calcium-Dependent Hormones

      • Paul Burnett, Lawrence D. Gaspers, Andrew P. Thomas

      Pages 153-175

   5. The Permeability Transition Pore in Myocardial Ischemia and Reperfusion

      • Andrew P. Halestrap, Paul M. Kerr, Sabzali Javadov, M-Saadah Suleiman

      Pages 177-199

   6. Mitochondrial Calcium Dysregulation during Hypoxic Injury to Cardiac Myocytes

      • Elinor J. Griffiths

      Pages 201-213

   7. Mitochondrial Implication in Cell Death

      • Patrice X. Petit

      Pages 215-246

   8. Role of Mitochondria in Apoptosis Induced by Tumor Necrosis Factor-α

      • Cynthia A. Bradham, Ting Qian, John J. Lemasters, Konrad Streetz, Christian Trautwein, David A. Brenner

      Pages 247-263

   9. The ATP Switch in Apoptosis

      • David J. McConkey

      Pages 265-277

5. Mitochondria, Free Radicals, and Disease

   1. Front Matter

      Pages 279-279

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   2. Reactive Oxygen Generation by Mitochondria

      • Alicia J. Kowaltowski, Anibal E. Vercesi

      Pages 281-300

   3. Role of the Permeability Transition in Glutamate-Mediated Neuronal Injury

      • Ian J. Reynolds, Teresa G. Hastings

      Pages 301-316

Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.

• ATP
• Calcium
• DNA
• Glutamat
• Lipid
• Oxidation
• Parkinson
• Purine
• genetic disorders
• metabolism

• University of North Carolina at Chapel Hill, Chapel Hill

  John J. Lemasters

• Case Western Reserve University, Cleveland

  Anna-Liisa Nieminen

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