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Advances in Experimental Medicine and Biology

The Biology and Pathology of Innate Immunity Mechanisms

Editors: Keisari, Yona, Ofek, Itzhak (Eds.)

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About this book

In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors.

Table of contents (25 chapters)

Table of contents (25 chapters)
  • Mannose Receptor and Scavenger Receptor: Two Macrophage Pattern Recognition Receptors with Diverse Functions in Tissue Homeostasis and Host Defense

    Pages 1-14

    Linehan, Sheena A. (et al.)

  • Complement Receptor 3 (CR3): A Public Transducer of Innate Immunity Signals in Macrophages

    Pages 15-25

    Yefenof, Eitan

  • The Role of C-type Lectins in the Innate Immunity Against Pulmonary Pathogens

    Pages 27-36

    Ofek, Itzhak (et al.)

  • Modulation of Nitric Oxide Production by Lung Surfactant in Alveolar Macrophages

    Pages 37-48

    Kalina, Moshe (et al.)

  • Development of Chimeric Collectins with Enhanced Activity Against Influenza a Virus

    Pages 49-59

    Hartshorn, Kevan L. (et al.)

Buy this book

eBook $149.00
price for USA in USD
  • ISBN 978-0-306-46831-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-306-46409-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $199.99
price for USA in USD
  • ISBN 978-1-4757-8647-7
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
The Biology and Pathology of Innate Immunity Mechanisms
Editors
  • Yona Keisari
  • Itzhak Ofek
Series Title
Advances in Experimental Medicine and Biology
Series Volume
479
Copyright
2002
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-0-306-46831-5
DOI
10.1007/b112037
Hardcover ISBN
978-0-306-46409-6
Softcover ISBN
978-1-4757-8647-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 330
Topics