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Advances in Experimental Medicine and Biology

Drug Resistance in Leukemia and Lymphoma III

Editors: Kaspers, G.J.L., Pieters, R., Veerman, A.J.P. (Eds.)

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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4615-4811-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
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  • Immediate eBook download after purchase
Hardcover $299.99
price for USA in USD
  • ISBN 978-0-306-46055-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4613-7180-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Cellular drug resistance is a major limitation to the success of chemotherapy of leu­ kemia and lymphoma. The importance of this has now been recognized by both clinicians and scientists. It is of utmost importance to bridge the gap between laboratory and clinic in this field of research. This is the main purpose of the series of International Symposia on Drug Resistance in Leukemia and Lymphoma. These are held every three years in Am­ sterdam, The Netherlands, since 1992. This book contains the proceedings of the third of these meetings, organised in 1998. The book covers all important aspects of drug resistance in leukemia and lymphoma, both in the form of extensive reviews as in manuscripts describing original data. General mechanisms of resistance are discussed, including the drug resistance related proteins p­ glycoprotein, MRP (multi-drug resistance protein) and LRP (lung resistance protein), and the role of glutathione and glutathione-S-transferases. Moreover, more drug type-specific mechanisms of resistance are a topic, such as for glucocorticoids and antifolates. Much in­ formation is provided on apoptosis and its regulators, and on the results of cell culture drug resistance assays. Several papers focus on the modulation or circumvention of drug resistance.

Table of contents (49 chapters)

  • MDR1/P-GP Expression as A Prognostic Factor in Acute Leukemias

    Marie, Jean-Pierre (et al.)

    Pages 1-9

  • Clinical Significance of P-Glycoprotein (P-gp) Expression in Childhood Acute Lymphoblastic Leukemia

    Dhooge, Catharina (et al.)

    Pages 11-19

  • Prognostic Value of P-gp Expression and Related Function in Childhood Acute Leukemia

    Karakaş, Z. (et al.)

    Pages 21-28

  • Comparison of P-Glycoprotein Expression and Function with in vitro Sensitivity to Anthracyclines in AML

    Elgie, Alena W. (et al.)

    Pages 29-33

  • Quinine Improves Results of Intensive Chemotherapy (IC) in Myelodysplastic Syndromes (MDS) Expressing P-Glycoprotein (PGP)

    Wattel, E. (et al.)

    Pages 35-46

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4615-4811-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.99
price for USA in USD
  • ISBN 978-0-306-46055-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4613-7180-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Drug Resistance in Leukemia and Lymphoma III
Editors
  • G.J.L. Kaspers
  • R. Pieters
  • A.J.P. Veerman
Series Title
Advances in Experimental Medicine and Biology
Series Volume
457
Copyright
1999
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-4811-9
DOI
10.1007/978-1-4615-4811-9
Hardcover ISBN
978-0-306-46055-5
Softcover ISBN
978-1-4613-7180-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIV, 638
Topics