Gene Therapy of Cancer

1. Front Matter

   Pages i-xvi

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2. Tumor Biology

   1. Expression Genetics in Cancer Research, Prognosis, and Therapy

      • Katherine J. Martin, R. Sager

      Pages 1-7

   2. Patterns of Chromosomal Imbalances in Carcinomas of the Respiratory Tract

      • Iver Petersen, Ulrike Bockmühl, Simone Petersen, Günter Wolf, Manfred Dietel

      Pages 9-16

   3. Inhibition of Tumorigenesis in a Murine B-Cell Lymphoma Transplant Model By c-Myc Complementary Oligonucleotides

      • Janet B. Smith, Eric Wickstrom

      Pages 17-22

   4. Telomerase Inhibition by Induced Expression of Antisense RNA

      • Antje Müller, G. Saretzki, T. von Zglinicki

      Pages 23-26

   5. Ex Vivo and In Vivo IGF-I Antisense RNA Strategies for Treatment of Cancer in Humans

      • D. D. Anthony, Y. X. Pan, S. G. Wu, F. Shen, Y. J. Guo

      Pages 27-34

   6. Use of the IGF-I Antisense Strategy in the Treatment of the Hepatocarcinoma

      • Lia C. Upegui-Gonzalez, Huynh T. Duc, Yves Buisson, Michel Arborio, Christiane Lafarge-Frayssinet, Claude Jasmin et al.

      Pages 35-42

   7. Functional Involvement of CD44, a Family of Cell Adhesion Molecules, in Immune Responses, Tumour Progression and Haematopoiesis

      • Ursula Günthert, C. Schwärzler, B. Wittig, J. Laman, P. Ruiz, R. Stauder et al.

      Pages 43-49

   8. The Influence of CD44 Splice Variants to the Outcome of Patients with Oral Squamous Cell Carcinoma

      • Christian Stoll, G. Baretton, F. Soost, U. Löhrs

      Pages 51-55

   9. Control of Tumor Growth Via Inhibition of Tumor Angiogenesis

      • Karl H. Plate

      Pages 57-61

   10. Expression of Collagenase-3 (MMP-13) by Tumor Cells in Squamous Cell Carcinomas of the Head and Neck

       • Veli-Matti Kähäri, N. Johansson, R. Grénman, K. Airola, U. Saarialho-Kere

       Pages 63-68

   11. High Level Expression of Tissue Inhibitors of Metalloproteinases-1,-2 and -3 in Melanoma Cells Achieved by Adenovirus Mediated Gene Transfer

       • M. Ahonen, A. H. Baker, Veli-Matti Kähäri

       Pages 69-72

   12. Tissue Inhibitor of Metalloproteinase Expression

       • A. M. McElligott, A. H. Baker, H. McGlynn

       Pages 73-77

   13. In Vivo Tumor Suppressor Effect of Retrovirus-Mediated Gene Transfer of the Adenovirus E1a Gene

       • R. Sanchez-Prieto, M. Quintanilla, A. Cano, M. Lleonart, P. Martin, Santiago Ramon y Cajal

       Pages 79-86

   14. Antitumor Effect of E1B Defective Adenoviruses in Human Malignant Cells

       • P. Martín Duque, C. Alonso, R. Sánchez-Prieto, M. Lleonart, Santiago Ramón y Cajal

       Pages 87-89

   15. Inhibition of Human Pancreatic Cancer Growth by the Adenovirus-Mediated Introduction of a Novel Growth Suppressing Gene, tob, In Vitro

       • Hironobu Yanagie, H. Sumimoto, Y. Nonaka, S. Matsuda, I. Hirose, S. Hanada et al.

       Pages 91-96

3. Chemogene Therapy

   1. Intratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy

      • Peter Karle, Petra Müller, Renate Renz, Ralf Jesnowski, Robert Saller, Kerstin von Rombs et al.

      Pages 97-106

   2. Sensitisation of Human Ovarian Cancer Cells to Killing by the Prodrug CB1954 Following Retroviral or Adenoviral Transfer of the E. coli Nitroreductase Gene

      • Peter F. Searle, S. J. Weedon, I. A. McNeish, M. G. Gilligan, M. J. Ford, F. Friedlos et al.

      Pages 107-113

   3. HSV-1 Thymidine Kinase Gene Therapy for Peritoneal Carcinomatosis

      • C. Lechanteur, F. Princen, S. Lo Bue, B. Detroz, G. Fillet, J. Gielen et al.

      Pages 115-119

   4. Characteristics of Cytosine Deaminase-5-Fluorocytosine System

      • Jaroslaw Szary, E. Missol, S. Szala

      Pages 121-123

The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.

• Herpes simplex
• Peptide
• angiogenesis
• apoptosis
• bone
• carcinoma
• endothelium
• tissue
• tumor growth
• tumorigenesis

• Humboldt University, Berlin, Germany

  Peter Walden, Uwe Trefzer, Wolfram Sterry, Patricia Zambon

• King’s College School of Medicine and Dentistry, London, UK

  Farzin Farzaneh

Policies and ethics