Advances in Lactoferrin Research

1. Front Matter

   Pages i-xiii

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2. Three-Dimensional Structure of Lactoferrin

   • Edward N. Baker, Bryan F. Anderson, Heather M. Baker, Ross T. A. MacGillivray, Stanley A. Moore, Neil A. Peterson et al.

   Pages 1-14

3. Structures of Buffalo and Mare Lactoferrins

   • A. K. Sharma, S. Karthikeyan, S. Sharma, S. Yadav, A. Srinivasan, T. P. Singh

   Pages 15-21

4. Direct Detection and Quantitative Determination of Bovine Lactoferricin and Lactoferrin Fragments in Human Gastric Contents by Affinity Mass Spectrometry

   • Hidefumi Kuwata, Tai-Tung Yip, Christine L. Yip, Mamoru Tomita, T. William Hutchens

   Pages 23-32

5. Analysis of Bovine Lactoferrin in Whey Using Capillary Electrophoresis (CE) and Micellar Electrokinetic Chromatography (MEKC)

   • Peter Riechel, Torsten Weiß, Roland Ulber, Heinrich Buchholz, Thomas Scheper

   Pages 33-39

6. Structural and Immunochemical Studies on Bovine Lactoferrin Fragments

   • Kei-ichi Shimazaki, Makoto Kamio, Myong Soo Nam, Shinji Harakawa, Tetsuya Tanaka, Yoshitaka Omata et al.

   Pages 41-48

7. Role of the First N-Terminal Basic Cluster of Human Lactoferrin (R2R3R4R5) in the Interactions with the Jurkat Human Lymphoblastic T-Cells

   • D. Legrand, P. H. C. van Berkel, V. Salmon, H. A. van Veen, M. C. Slomianny, J. H. Nuijens et al.

   Pages 49-55

8. Glycation Ligand Binding Motif in Lactoferrin

   • Yong Ming Li

   Pages 57-63

9. Mouse Lactoferrin Gene

   • Christina Teng, Huiping Shi, Nengyu Yang, Hiroyuki Shigeta

   Pages 65-78

10. Cloning of Human Genomic Lactoferrin Sequence and Expression in the Mammary Glands of Transgenic Animals

    • Sun Jung Kim, Dae-Yeul Yu, Yong-Mahn Han, Chul-Sang Lee, Kyung-Kwang Lee

    Pages 79-83

11. Expression of Human Lactoferrin in Transfected Rat Mammary Epithelial Cells

    • Haruto Kumura, Yoriko Hiramatsu, Yukako Ukai, Katsuhiko Mikawa, Kei-ich Shimazaki

    Pages 85-89

12. Restricted Spatiotemporal Expression of Lactoferrin during Murine Embryogenesis

    • Pauline P. Ward, Marisela M. Mendoza, Odila Saucedo-Cardenas, Christina T. Teng, Orla M. Conneely

    Pages 91-100

13. Construction of Recombinant Chimeric Human Lactoferrin/Bovine Transferrins

    • Henry Wong, Anthony B. Schryvers

    Pages 101-106

14. The LDL-Receptor Family

    • M. Huettinger, M. Meilinger, Ch. Gschwentner, H. Lassmann

    Pages 107-111

15. Identification and Analysis of a Ca2+-Dependent Lactoferrin Receptor in Rat Liver

    • Douglas D. McAbee, David J. Bennatt, Yuan Yuan Ling

    Pages 113-121

16. Bacterial Lactoferrin Receptors

    • Anthony B. Schryvers, Robert Bonnah, Rong-hua Yu, Henry Wong, Mark Retzer

    Pages 123-133

17. Evidence for the Existence of a Surface Receptor(s) for Ferriclactoferrin and Ferrictransferrin Associated with the Plasma Membrane of the Protozoan Parasite Leishmania donovani

    • Bradley E. Britigan, Troy S. Lewis, Michael L. McCormick, Mary E. Wilson

    Pages 135-140

18. Lactoferrin Secretion into Mouse Milk

    • Margaret C. Neville, Katie Chatfield, Linda Hansen, Andrew Lewis, Jenifer Monks, Jan Nuijens et al.

    Pages 141-153

19. Lactoferrin in Duodenal Aspirates during Childhood

    • G. Sawatzki, G. Georgi, Th. Richter, G. Moro, G. Boehm

    Pages 155-159

20. Iron in Synovial Fluid

    • C. Guillen, I. B. McInnes, J. H. Brock

    Pages 161-165

Following the two meetings on Lactoferrin Structure and Function that were held in Honolulu, Hawaii, in 1993 and 1995, the Third International Conference on Lactoferrin Structure and Function was held in Le Touquet, France, and has successfully reinforced and diversified the previously created bridges between biochemists, clinicians, and companies. In fact, scientists, physicians, and people of industry from different domains have brought a wealth of recent information concerning biochemistry and technical advances in the identification of lactoferrin-derived compounds as well as cell biology, molecular biol­ ogy, pathology, and medical applications of lactoferrin and lactoferrin-derived com­ pounds. We were so delighted with the rapid growth of knowledge concerning many biologi­ cal and immunological functions of lactoferrins and the relationships between their struc­ ture and function, we wanted to share our pleasure with the readers interested in this field. The present book. which represents a review of some of the most exciting contributions, is intended to reflect the status of our knowledge and transmit our hopes for the future devel­ opment of in vivo applications of natural and recombinant lactoferrins. We would like to express our gratitude to the sponsors who contributed to the or­ ganization of the meeting in such a pleasant place and allowed the participation of several young researchers. We would also like to thank all the participants who have answered with enthusiasm our invitation and to every one of the Laboratoire de Chimie Biologique for the constant and efficient help.

• Promoter
• Termination
• biochemistry
• biology
• cell biology
• chemistry
• protein
• transgenic animals

• Université des Sciences et Technologies de Lille, Villeneuve d’Ascq, France

  Geneviève Spik, Dominique Legrand, Joël Mazurier, Annick Pierce

• Biopole, Brussels, Belgium

  Jean-Paul Perraudin

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