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Enzyme-Prodrug Strategies for Cancer Therapy

Editors: Melton, Roger G., Knox, Richard J. (Eds.)

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eBook $189.00
price for USA in USD (gross)
  • ISBN 978-1-4615-4823-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA in USD
  • ISBN 978-0-306-45895-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4613-7186-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Antibody-directed enzyme prodrug therapy (ADEPT) directly addresses the major problem in cancer chemotherapy-its lack of selectivity. Antibody delivery combined with the amplification provided by the enzymatic activation of prodrugs enables selection to be made between tumour and normal tissue. ADEPT offers a novel field of opportunities in the therapy of systemic cancer and may be a major advance for the treatment of solid tumours.
This book is the first to describe ADEPT in detail. Each chapter reviews an aspect of the immunology, enzymology, biochemistry, chemistry, and cancer chemotherapy which have been integrated into the ADEPT concept. An additional chapter describes the related approach of gene-directed enzyme prodrug therapy (GDEPT). This latter approach is still in its infancy but ADEPT has entered the clinic. The initial clinical studies with ADEPT are included and discussed in detail.

Table of contents (9 chapters)

  • Introduction

    Knox, Richard J. (et al.)

    Pages 1-9

  • Prodrugs in Cancer Chemotherapy

    Connors, Tom

    Pages 11-37

  • Factors Influencing Tumor-Selective Localization of Antibody Conjugates

    Sims, M. A. (et al.)

    Pages 39-96

  • Enzymes and Prodrugs Used for ADEPT

    Knox, Richard J.

    Pages 97-131

  • The Design and Synthesis of Prodrugs for Antibody-Directed Enzyme Prodrug Therapy (ADEPT)

    Burke, P. J.

    Pages 133-154

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-1-4615-4823-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA in USD
  • ISBN 978-0-306-45895-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4613-7186-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Enzyme-Prodrug Strategies for Cancer Therapy
Editors
  • Roger G. Melton
  • Richard J. Knox
Copyright
1999
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-4823-2
DOI
10.1007/978-1-4615-4823-2
Hardcover ISBN
978-0-306-45895-8
Softcover ISBN
978-1-4613-7186-1
Edition Number
1
Number of Pages
XIII, 257
Topics