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- About this book
-
There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.
- Table of contents (126 chapters)
-
-
Selective Thermal Neutron Capture Therapy of Cancer Cells Using their Specific Metabolic Activities—Melanoma as Prototype
Pages 1-26
Mishima, Yutaka
-
Recent Results with Liposomes as Boron Delivery Vehicles for Boron Neutron Capture Therapy
Pages 27-36
Hawthorne, M. Frederick (et al.)
-
Preparation of Epidermal Growth Factor Conjugates Aimed for Boron Neutron Capture Therapy
Pages 37-42
Gedda, Lars (et al.)
-
Epidermal Growth Factor (EGF) as a Potential Targeting Agent for Delivery of Boron to Malignant Gliomas
Pages 43-48
Capala, Jacek (et al.)
-
Boron Neutron Capture Therapy Against Tumor Cells with Overexpression of the EGF-Receptor
Pages 49-56
Carlsson, Jörgen (et al.)
-
Boron-Rich Oligophosphates — Novel Molecules for Use in BNCT
Pages 57-65
Kane, Robert R. (et al.)
-
Potential Use of Bispecific Antibodies (BSABS) for Targeting Gliomas and Melanomas
Pages 67-73
Liu, Liang (et al.)
-
Effect of Intratumoral Injection of 10B-Immunoliposome on BNCT for Growth Inhibition of Human Pancreatic Cancer Grafts in Nude Mice
Pages 75-79
Yanagië, Hironobu (et al.)
-
Chemical Modeling with p-Boronophenylalanine for Boron Accumulation to and Release from Melanoma
Pages 81-90
Yoshino, Kazuo (et al.)
-
Chemical Properties of p-, m-, o-Boronophenylalanine
Pages 91-97
Yoshino, Kazuo (et al.)
-
An Efficient Synthesis of p-Boronophenylalanine and Its Homologues by the Reaction of Ethyl Isocyanoacetate with a p-Formylbenzeneboronic Acid Derivative
Pages 99-104
Kirihata, Mitsunori (et al.)
-
New Unnatural Boron-Containing Amino Acids and Peptides as Potential Delivery Agents for Neutron Capture Therapy
Pages 105-110
Wyzlic, Iwona M. (et al.)
-
Study of the Interaction of P-Boronophenylalanine and Its Analogs with Various Carboxylic Acids by Using Zone Electrophoresis
Pages 111-114
Kitaoka, Yoshinori (et al.)
-
Examination of Stability of p-, m-, o-Boronophenylalanine in Blood with High Performance Liquid Chromatography
Pages 115-120
Yoshino, Kazuo (et al.)
-
Synthesis and Initial Biological Evaluation of Carborane-Containing Phenanthridinium Derivatives
Pages 121-126
Tjarks, Werner (et al.)
-
Chemical Behavior of Boron-Containing Amino Acids for Neutron Capture Therapy in Aqueous Solutions
Pages 127-130
Kobayashi, Mitsue (et al.)
-
Asymmetric Synthesis of o- and p-Carboranyl Amino Acids
Pages 131-136
Malmquist, Jonas (et al.)
-
Synthesis, Tissue Uptake, and Toxicity of a Nickel Tetracarboranylphenylporphyrin
Pages 137-141
Miura, Michiko (et al.)
-
Optimization of Drug Anchor for Ortho-Carborane in Reconstitution of Low Density Lipoproteins for Neutron Capture Therapy
Pages 143-149
Smith, Michael D. (et al.)
-
Synthesis of 5-S-Alkylcarboranyl-2′-Deoxyuridines
Pages 151-155
Lunato, Anthony J. (et al.)
-
Synthesis of Boronated Uridine Derivatives for Boron Neutron Capture Therapy
Pages 157-161
Kabalka, G. W. (et al.)
-
New Small Molecular Weight Agents for Boron Neutron Capture Therapy
Pages 163-166
Soloway, A. H. (et al.)
-
Synthesis and Biochemical Evaluation of 5-Tethered Boron-Containing Pyrimidine Nucleosides for BNCT
Pages 167-171
Rong, Feng-Guang (et al.)
-
Synthesis of a Water-Soluble o-Carborane Bearing Uracil Moiety Via Palladium Catalyzed Reaction under Essentially Neutral Conditions
Pages 173-176
Nemoto, Hisao (et al.)
-
Netropsin and Distamycin Analogues Bearing Ortho-Carborane
Pages 177-182
Yamamoto, Yoshinori (et al.)
-
Spatial and Temporal Distribution of Boron Uptake in Excised Samples of Human Rheumatoid Synovium
Pages 183-188
Johnson, L. S. (et al.)
-
Analysis of Boron in LDL-Matrix
Pages 189-195
Savolainen, Sauli (et al.)
-
Non-Linear Regression between Track Density and 10B Concentration in Photo-Electronic Neutron Capture Radiography
Pages 197-202
Pignol, J. P. (et al.)
-
New Developments in the Use of Solid State Nuclear Track Detectors
Pages 203-208
Teichmann, S. (et al.)
-
Subcellular Localization of a Boronated Nucleoside Using Ion Microscopy
Pages 209-213
Gay, Isabelle (et al.)
-
Ion Microscopy Imaging of Boron from BNCT Drugs in Cryogenically Prepared Tissues
Pages 215-220
Smith, Duane R. (et al.)
-
Application of Neutron-Induced Prompt Gamma-Ray Analysis for Determination of B-10 in BNCT
Pages 221-225
Yonezawa, Chushiro (et al.)
-
Foundations for Boron Neutron Capture Therapy of High-Grade Astrocytomas
Pages 227-232
Salford, L. G. (et al.)
-
Noninvasive in-vivo Detection of Boron-10 by Magnetic Resonance
Pages 233-238
Bendel, Peter (et al.)
-
Determination of Mn-BOPP Concentrations Using Neutron Activation Analysis and MRI
Pages 239-244
Combs, Matthew J. (et al.)
-
Boron-, Gadolinium-Porphyrin Derivatives for Neutron Capture Therapy
Pages 245-250
Matsumura, Akira (et al.)
-
The Measurement of Gadolinium Concentration in Rat Brain Tumor with NMR Analyzer for Neutron Capture Therapy
Pages 251-255
Shibata, Y. (et al.)
-
Procedures for the Medical Application of Research Reactors
Pages 257-260
Nishihara, Hideaki (et al.)
-
On-Line Beam Monitoring for Boron Neutron Capture Therapy at the MIT Research Reactor
Pages 261-269
Harling, O. K. (et al.)
-
Status of the BNCT Project at the HFR Petten
Pages 271-279
Moss, R. L.
-
Physics of Boron Neutron Capture Therapy in Japan
Pages 281-288
Kanda, Keiji
-
Improvements in Patient Treatment Planning Systems
Pages 289-294
Wheeler, Floyd J. (et al.)
-
Monte Carlo Neutron Photon Treatment Planning Calculations
Pages 295-302
Wallace, S. A. (et al.)
-
Validation of Monte Carlo Dose Planning Calculations by Epithermal Beam Dose Distribution Measurements in Phantoms
Pages 303-310
Carolan, M. G. (et al.)
-
Design Study on Triangular-Hexagonal Triga Core for Epithermal Neutron Irradiation
Pages 311-317
Aizawa, Otohiko
-
Development of the ECN Argonaut Reactor for BNCT Studies
Pages 319-325
Stecher-Rasmussen, F. (et al.)
-
The Boron Neutron Capture Therapy Research Facility at the Tehran Research Reactor (TRR)
Pages 327-335
Marashi, M. K. (et al.)
-
Epithermal Neutron Beam Design for Neutron Capture Therapy at Tsing Hua Open-Pool Reactor
Pages 337-342
Su, L. (et al.)
-
Upgrades of the Epithermal Neutron Beam at the Brookhaven Medical Research Reactor
Pages 343-348
Liu, Hungyuan B. (et al.)
-
A Direct Comparison of Neutron Energy Spectra at High and Low Powers in the HB11 Beam at H.F.R. Petten
Pages 349-355
Crawford, J. F. (et al.)
-
Conceptual Design for an Epithermal-Neutron Beam for Boron Neutron Capture Therapy at the Georgia Institute of Technology Research Reactor
Pages 357-364
Klee, Kathleen A. (et al.)
-
Remodeling of the Heavy-Water Facility of the Kyoto University Reactor for Epithermal and Thermal Neutrons
Pages 365-374
Kobayashi, Tooru (et al.)
-
The Utilization of Hyper-Thermal Neutrons for Neutron Capture Therapy
Pages 375-384
Sakurai, Yoshinori (et al.)
-
Epithermal-Neutron Beam Design for Neutron Capture Therapy at the Tsing-Hua Open Pool Reactor (THOR)
Pages 385-391
Liu, Hong-Ming
-
The IEC Neutron Generator and Filter Concept for Neutron Capture Therapy
Pages 393-398
Nadler, J. H. (et al.)
-
Capillary Neutron Optics for Boron Neutron Capture Therapy
Pages 399-406
Xiao, Q. F. (et al.)
-
High-Intensity Fission-Converter-Based Epithermal Neutron Beam for Neutron Capture Therapy
Pages 407-412
Harling, Otto K. (et al.)
-
A Study of the Concept of a Fission-Plate Converter as a Source for an Epithermal Neutron Beam
Pages 413-418
Liu, Hungyuan B. (et al.)
-
Design of Epithermal Neutron Beams Using Spent Fuel Elements at the Musashi Reactor
Pages 419-424
Matsumoto, Tetsuo (et al.)
-
An Accelerator-Based Epithermal Photoneutron Source for BNCT
Pages 425-430
Nigg, David W. (et al.)
-
Conceptual Design of a Deuteron Linac Facility for Boron Neutron Capture Therapy
Pages 431-437
Hirota, Jitsuya (et al.)
-
Shielding Design and Dose Assessment for an Accelerator-Based BNCT Facility
Pages 439-444
Howard, W. B. (et al.)
-
Neutron Generator as a Neutron Source for BNCT
Pages 445-450
Shani, Gad (et al.)
-
Beam Profiles of an Epithermal Neutron Beam
Pages 451-456
Raaijmakers, C. P. J. (et al.)
-
Mixed Field Dosimetry of Neutron Beams for Boron Neutron Capture Therapy at the Massachusetts Institute of Technology
Pages 457-466
Rogus, Ronald D. (et al.)
-
Determination of Boron Dose for BNCT Using Fricke and EPR Dosimetry
Pages 467-471
Wielopolski, L. (et al.)
-
Simultaneous Monitoring System of Neutron Fluence Rate Distribution by Detectors with Multiple Sensitive Heads
Pages 473-477
Hayakawa, Y. (et al.)
-
Dose Sparing of Capillary Endothelial Cells for BSH and BPA
Pages 479-483
Charlton, D. E. (et al.)
-
A Microdosimetry Model for BNCT Analysis
Pages 485-493
Vroegindeweij, Corine (et al.)
-
A Microdosimetry Model for In Vitro Boron Neutron Capture Irradiation Experiments Using d(14)+Be-Neutrons
Pages 495-500
Pöller, F. (et al.)
-
Computational Dosimetry of BNCT for Breast Cancer Treatment
Pages 501-509
Weldy, James B. (et al.)
-
Phantoms for Neutron Capture Therapy Dosimetry
Pages 511-516
Harling, O. K. (et al.)
-
Measurements of Depth-Dose Distributions in a Phantom for Gadolinium Neutron Capture Therapy
Pages 517-522
Matsumoto, Tetsuo (et al.)
-
Theoretical Evaluation of the Dose Distribution for Gadolinium Neutron Capture Therapy
Pages 523-526
Wierzbicki, Jacek G. (et al.)
-
Calculated Electron Spectra for Gadolinium Neutron Capture Therapy
Pages 527-532
Maeda, Tatsuya (et al.)
-
Biologic Considerations in Targeting Brain tumors for Boron Neutron Capture Therapy
Pages 533-539
Barth, Rolf F.
-
T1 Measurement to Study the Penetration of BNCT Agents Into Canine Tumors Caused by Blood Brain Barrier Damage
Pages 541-546
Tang, Peng-Peng P. Zhu (et al.)
-
Enhanced Tumor Uptake of Boronophenylalanine by Means of Osmotic Blood-Brain Barrier Disruption in Glioma—Bearing Rats
Pages 547-551
Yang, Weilian (et al.)
-
Boron Neutron Capture Therapy of Glioblastoma Multiforme Using the p-Boronophenylalanine-Fructose Complex and Epithermal Neutrons
Pages 553-561
Coderre, J. A. (et al.)
-
The Dose Planning of BNCT for Brain Tumors
Pages 563-569
Ono, K. (et al.)
-
Effectiveness of Borocaptate Sodium for Boron Neutron Capture Therapy in Malignant Brain Tumors
Pages 571-578
Takagaki, Masao (et al.)
-
Evaluation of Response to Thermal Neutron Irradiation in Quiescent Cell Populations Within Murine Solid Tumors Using Micronucleus Assay
Pages 579-584
Masunaga, Shin-ichiro (et al.)
-
Assessment of Radiation Induced Damage of Mouse Brain Using 18F-2-Deoxy-D-Glucose and 99mTc-Hexamethylpropylene Amine Oxine
Pages 585-590
Abe, Yoshinao (et al.)
-
Brain Tolerance in Dogs to Boron Neutron Capture Therapy with Borocaptate Sodium (BSH) or Boronophenylalanine (BPA)
Pages 591-598
Huiskamp, R. (et al.)
-
Pharmacokinetics and Effects of Neutron Capture on Melanoma Xenografts after Administration of Boronated Low Density Lipoprotein
Pages 599-604
Setiawan, Yohanes (et al.)
-
Toxicology and Pharmacokinetics of BOPP in a Canine Model
Pages 605-610
Kahl, Stephen B. (et al.)
-
Acute Toxicity of Elaidyl-1,2,-Carborane Carboxylate (ECC) in Rats
Pages 611-613
Kallio, Merja (et al.)
-
ESR Study of Hydroxyl Radicals, Superoxide Anion Radicals and Molecular Singlet Oxygen Generated by Mercaptoundecahydro-closo-Dodecaborate(2-) Solution Irradiated by Neutrons under Conditions of Boron Neutron Capture Reaction
Pages 615-619
Stopka, Pavel (et al.)
-
Boron Neutron Capture Therapy of Uveal Melanoma
Pages 621-625
Pignol, J. P. (et al.)
-
Binding and Immunohistochemical Localization of Na2B12H11SH to Tumor Tissue of Glioma Patients in Boron Neutron Capture Therapy
Pages 627-633
Otersen, Birte (et al.)
-
Pharmacokinetics and Biodistribution in Patients with Malignant Glioma after Administration of N-Acetylcysteine (N-AC) Prior to Borocaptate Sodium (BSH)
Pages 635-641
Haritz, Dietrich (et al.)
-
Additional Impurities Identified in Borocaptate Sodium
Pages 643-648
Bauer, W. F. (et al.)
-
Uptake and Distribution of the Boron Containing Ether Lipid B-ET-11-OMe in Tumor Bearing Mice
Pages 649-654
Lemmen, Peter (et al.)
-
Uptake and Biological Effects of the Carborane Based Boron Compounds DAC-1 and DAAC-1
Pages 655-661
Olsson, Pär (et al.)
-
BNCT of Malignant Melanoma-Radiobiological Analysis and Data Comparison with Conventional Radiotherapy
Pages 663-671
Fukuda, Hiroshi (et al.)
-
Re-Evaluation of Skin RBE for Clinical BNCT of Malignant Melanoma
Pages 673-677
Hiratsuka, Junichi (et al.)
-
Boron Analytical Studies on 10B1-BPA Administration for Neutron Capture Therapy of Malignant Melanoma
Pages 679-683
Honda, C. (et al.)
-
Pharmacokinetic Comparison Between L & D, L-BPA. Fructose in a Murine Melanoma Model and in Human Patients with Metastatic Melanoma
Pages 685-690
Moore, Douglas E. (et al.)
-
A Basic Concept for PET-BNCT System
Pages 691-696
Imahori, Y. (et al.)
-
Two Cases of Primary Malignant Melanoma Treated by Selective Melanoma Thermal Neutron Capture Therapy
Pages 697-705
Watanabe, Kazumi (et al.)
-
A Phase-I Dose-Escalation Trial of Boron Neutron Capture Therapy for Subjects with Metastatic Subcutaneous Melanoma of the Extremities
Pages 707-716
Madoc-Jones, H. (et al.)
-
Recent Study of Boron Neutron Capture Therapy for Malignant Brain Tumor in Japan
Pages 717-724
Nakagawa, Yoshinobu (et al.)
-
Boron Neutron Capture Therapy for Malignant Brain Tumors in Children
Pages 725-731
Nakagawa, Yoshinobu (et al.)
-
Blood-Brain Barrier Disruption (BBB-D) in Rats
Pages 733-738
Carpenter, David E. (et al.)
-
A Phase 1 Trial of Intravenous Boronophenylalanine-Fructose Complex in Patients with Glioblastoma Multiforme
Pages 739-745
Bergland, R. (et al.)
-
BNCT Microdosimetry and Brain-Tumor Patient Response
Pages 747-756
Griebenow, M. L. (et al.)
-
The Therapeutic Ratio in BNCT
Pages 757-762
Coderre, J. A. (et al.)
-
Boron Neutron Capture Therapy of Spontaneous Intracranial Tumors in Dogs
Pages 763-768
Gavin, P. R. (et al.)
-
Sodium Borocaptate and Boronopheynlalanine Alone or in Combination as Capture Agents for BNCT of the F98 Rat Glioma
Pages 769-775
Barth, Rolf F. (et al.)
-
BNCT as an Adjuvant to Fast Neutron Radiotherapy for Selected Tumor Systems
Pages 777-782
Laramore, G. E. (et al.)
-
Development of a Method to Use Boron Neutron Capture Therapy for Diffused Tumours of Liver (Taormina Project)
Pages 783-794
Pinelli, T. (et al.)
-
Evidence for a Null Effect of L-10BPA Neutron Capture Therapy on Mouse Brain Dopamine Tracts
Pages 795-801
Allen, Barry J. (et al.)
-
Microvasculature Casting Technique for Capillary Endothelial Damage after BNCT
Pages 803-808
Mallesch, Julia (et al.)
-
Normal Tissue Tolerance and Fractionation Effects in Dogs of Boron Neutron Capture Irradiation with Borocaptate Sodium (BSH)
Pages 809-814
Philipp, Katharina H. I. (et al.)
-
The Compound Factor of NA2B12H11SH and the Relative Biological Effectiveness of Recoil Protons for Neurological Damage in Boron Neutron Capture Therapy
Pages 815-821
Gabel, Detlef (et al.)
-
Positron Emission Tomography and Boron Neutron Capture Therapy System to the Patient with Malignant Brain Tumor
Pages 823-827
Ueda, S. (et al.)
-
Selective Detection of Brain Metastasis of Malignant Melanoma Using 18F-10B-L-Borono-Phenylalanine with Positron Emission Tomography
Pages 829-833
Ehara, Kazumasa (et al.)
-
In Vivo NMR Evaluation of the Pharmacokinetics of Boronated Compounds in the Rat Model
Pages 835-841
Hendee, Shonn P. (et al.)
-
Boron MRI in a Tumor Bearing Canine Model
Pages 843-847
Schweizer, Martin P. (et al.)
-
First Boron MRI of a Human Patient with a Brain Tumor
Pages 849-853
Bradshaw, Kenneth M. (et al.)
-
Assessment of Photon Contributions in Gadolinium Neutron Capture Reactions-A Preliminary Study
Pages 855-858
Tokuuye, Koichi (et al.)
-
Gadolinium Neutron Capture Therapy (GdNCT) with MRI Contrast Media. In Vitro Studies
Pages 859-864
Lawaczeck, R. (et al.)
-
Neutron Capture Therapy with Gd-DTPA in Tumor-Bearing Rats
Pages 865-869
Khokhlov, V. F. (et al.)
-
Clinical Californium-252 Boron Neutron Capture Enhancement
Pages 871-875
Maruyama, Yosh (et al.)
-
Dedication to the Memory of Professor Hiroshi Hatanaka
Pages 877-879
Mishima, Yutaka
-
Noted Authority on Neutron Therapy Dies in January 1995
Pages 881-882
Mishima, Yutaka
-
Table of contents (126 chapters)
Buy this book
- eBook $269.00
-
price for USA in USD
- ISBN 978-1-4757-9567-7
- Digitally watermarked, DRM-free
- Included format: EPUB, PDF
- ebooks can be used on all reading devices
- Immediate eBook download after purchase
- Hardcover $459.00
-
price for USA in USD
- ISBN 978-0-306-45307-6
- Free shipping for individuals worldwide
- Institutional customers should get in touch with their account manager
- Covid-19 shipping restrictions & severe weather in the US may cause delays
- Usually ready to be dispatched within 3 to 5 business days, if in stock
- Softcover $349.99
-
price for USA in USD
- ISBN 978-1-4757-9569-1
- Free shipping for individuals worldwide
- Institutional customers should get in touch with their account manager
- Covid-19 shipping restrictions & severe weather in the US may cause delays
- Usually ready to be dispatched within 3 to 5 business days, if in stock
Services for this Book
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- Cancer Neutron Capture Therapy
- Editors
-
- Y. Mishima
- Copyright
- 1996
- Publisher
- Springer US
- Copyright Holder
- Springer-Verlag US
- eBook ISBN
- 978-1-4757-9567-7
- DOI
- 10.1007/978-1-4757-9567-7
- Hardcover ISBN
- 978-0-306-45307-6
- Softcover ISBN
- 978-1-4757-9569-1
- Edition Number
- 1
- Number of Pages
- XXVII, 920
- Topics
