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Technologies for Detection of DNA Damage and Mutations

Editors: Pfeifer, G.P. (Ed.)

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  • ISBN 978-1-4899-0301-3
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Softcover $219.99
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About this book

Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote genetic alterations (mutations) that may be linked to an altered phenotype, and, if growth-controlling genes are involved, these mutations can lead to cell transformation and the development of malignant tumors. Proto­ oncogenes and tumor suppressor genes may be critical targets for DNA damaging agents. In a number of animal model systems, correlations between exposure to a carcinogen, tumor develop­ ment, and genetic changes in tumor DNA have been established. To understand mutagenesis processes in more detail at the molecular level, we need to know the type and frequency of DNA adducts within cells, their distribution along genes and specific DNA sequences, as well as the rates at which they are repaired. We also need to know what types of mutations are produced and which gene positions are most prone to mutagenesis. This book provides a collection of techniques that are useful in mutagenesis research. The book is divided into three parts. In Part I, methods for DNA damage and repair analysis are provided.

Table of contents (31 chapters)

  • Microgel Electrophoresis of DNA from Individual Cells

    Singh, Narendra P.

    Pages 3-24

  • The Cytokinesis-Block Micronucleus Technique

    Fenech, Michael F.

    Pages 25-36

  • Agarose Gel Electrophoresis for DNA Damage Analysis

    Drouin, Régen (et al.)

    Pages 37-43

  • 32P-Postlabeling for Detection of DNA Adducts

    Gupta, R. C.

    Pages 45-61

  • A Postlabeling Assay for Oxidative Damage

    Weinfeld, Michael (et al.)

    Pages 63-71

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4899-0301-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.99
price for USA in USD
  • ISBN 978-0-306-45237-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4899-0303-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Technologies for Detection of DNA Damage and Mutations
Editors
  • G.P. Pfeifer
Copyright
1996
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4899-0301-3
DOI
10.1007/978-1-4899-0301-3
Hardcover ISBN
978-0-306-45237-6
Softcover ISBN
978-1-4899-0303-7
Edition Number
1
Number of Pages
XXVI, 441
Topics