Biological Reactive Intermediates V

1. Front Matter

   Pages i-xiv

   PDF

2. Session I

   1. New Biological Reactive Intermediates

      • Daniel Mansuy, Patrick M. Dansette

      Pages 1-6

   2. Activation of Toxic Chemicals by Cytochrome P450 Enzymes

      • F. Peter Guengerich, Yune-Fang Ueng, Bok-Ryang Kim, Sophie Langouet, Brian Coles, Rajkumar S. Iyer et al.

      Pages 7-15

   3. Investigating the Role of the Microsomal Epoxide Hydrolase Membrane Topology and Its Implication for Drug Metabolism Pathways

      • Thomas Friedberg, Bettina Löllmann, Roger Becker, Romy Holler, Michael Arand, Franz Oesch

      Pages 17-24

   4. Cytotoxicity of Nitric Oxide and Hydrogen Peroxide

      • Iosif Ioannidis, Thomas Volk, Herbert de Groot

      Pages 25-30

   5. Development of a Mass Spectrometric Assay for 5,6,7,9-Tetrahydro-7-Hydroxy-9-Oximidazo [1,2-a]Purine in DNA Modified by 2-Chloro-Oxirane

      • Michael Müller, Frank Belas, Hitoshi Ueno, F. Peter Guengerich

      Pages 31-36

3. Session II

   1. Reactions of Reactive Metabolites with Hemoproteins—Toxicological Implications

      • Yoichi Osawa, Kashime Nakatsuka, Mark S. Williams, James T. Kindt, Mikiya Nakatsuka

      Pages 37-45

   2. Immunochemical Detection of Drug-Protein Adducts in Acetaminophen Hepatotoxicity

      • Jack A. Hinson, Dean W. Roberts, N. Christine Halmes, Jennifer D. Gibson, Neil R. Pumford

      Pages 47-55

   3. An Oxidant Sensor at the Plasma Membrane

      • Axel Knebel, Mihail Iordanov, Hans J. Rahmsdorf, Peter Herrlich

      Pages 57-62

   4. Identification of Hydrogen Peroxide as the Relevant Messenger in the Activation Pathway of Transcription Factor NF-κB

      • Kerstin N. Schmidt, Paul Amstad, Peter Cerutti, Patrick A. Baeuerle

      Pages 63-68

   5. Redox Regulation of Ap-1

      • Steven Xanthoudakis, Tom Curran

      Pages 69-75

   6. The Transcription Factor TCF/Elk-1

      • Judith M. Müller, Michael A. Cahill, Alfred Nordheim, Patrick A. Baeuerle

      Pages 77-84

4. Session III

   1. Some Activities of the Oxidant Chromate

      • Hyoung-Sook Park, Sean O’Connell, Saul Shupack, Edward Yurkow, Charlotte M. Witmer

      Pages 85-96

   2. Reactive Dopamine Metabolites and Neurotoxicity

      • Teresa G. Hastings, David A. Lewis, Michael J. Zigmond

      Pages 97-106

   3. Selective Depletion of Mitochondrial Glutathione Content by Pivalic Acid and Valproic Acid in Rat Liver

      • U. Zanelli, P. Puccini, D. Acerbi, P. Ventura, P. G. Gervasi

      Pages 107-111

   4. Regulation of the Superoxide Releasing System in Human Fibroblasts

      • Beate Meier

      Pages 113-116

   5. Studies on the Mechanism of Phototoxicity of BAY y 3118 and Other Quinolones

      • U. Schmidt, G. Schlüter

      Pages 117-120

   6. 4-Oxo-Retinoic Acid Is Generated from Its Precursor Canthaxanthin and Enhances Gap Junctional Communication in 10T1/2 Cells

      • Wilhelm Stahl, Michael Hanusch, Helmut Sies

      Pages 121-128

   7. Hepatic Epoxide Concentrations during Biotransformation of 1,2- and 1,4-Dichlorobenzene

      • Erna Hissink, Ben van Ommen, Jan J. Bogaards, Peter J. van Bladeren

      Pages 129-133

   8. Oxygen Radical Formation Due to the Effect of Varying Hydrogen Ion Concentrations on Cytochrome P450-Catalyzed Cyclosporine Metabolism in Rat and Human Liver Microsomes

      • S. Sohail Ahmed, Kimberly L. Napoli, Henry W. Strobel

      Pages 135-139

Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam­ ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi­ cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

• Oxidation
• biochemistry
• cytochrome P450
• dopamine
• enzymes
• metabolism
• neurotoxicity
• proteins

• Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, USA

  Robert Snyder, Charlotte M. Witmer

• University of Arizona, Tuscon, USA

  I. Glenn Sipes

• Medical University of South Carolina, Charleston, USA

  David J. Jollow

• University of Texas, Austin, USA

  Terrence J. Monks

• Thomas Jefferson University, Philadelphia, USA

  James J. Kocsis, George F. Kalf

• GSF Institute of Toxicology, Technical University, Munich, Germany

  Helmut Greim

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