Get 40% off our selection of bestselling print books in Engineering through October 31st!

Advances in Experimental Medicine and Biology

Biological Reactive Intermediates V

Basic Mechanistic Research in Toxicology and Human Risk Assessment

Editors: Snyder, R.R., Kocsis, J.J., Sipes, I.G., Kalf, G.F., Jollow, D.J., Greim, H., Monks, T.J., Witmer, C.M. (Eds.)

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-1-4757-9480-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $329.00
price for USA in USD
  • ISBN 978-0-306-45197-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-1-4757-9482-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam­ ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi­ cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

Table of contents (49 chapters)

  • New Biological Reactive Intermediates

    Mansuy, Daniel (et al.)

    Pages 1-6

  • Activation of Toxic Chemicals by Cytochrome P450 Enzymes

    Guengerich, F. Peter (et al.)

    Pages 7-15

  • Investigating the Role of the Microsomal Epoxide Hydrolase Membrane Topology and Its Implication for Drug Metabolism Pathways

    Friedberg, Thomas (et al.)

    Pages 17-24

  • Cytotoxicity of Nitric Oxide and Hydrogen Peroxide

    Ioannidis, Iosif (et al.)

    Pages 25-30

  • Development of a Mass Spectrometric Assay for 5,6,7,9-Tetrahydro-7-Hydroxy-9-Oximidazo [1,2-a]Purine in DNA Modified by 2-Chloro-Oxirane

    Müller, Michael (et al.)

    Pages 31-36

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-1-4757-9480-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $329.00
price for USA in USD
  • ISBN 978-0-306-45197-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.99
price for USA in USD
  • ISBN 978-1-4757-9482-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Biological Reactive Intermediates V
Book Subtitle
Basic Mechanistic Research in Toxicology and Human Risk Assessment
Editors
  • Robert R. Snyder
  • James J. Kocsis
  • I. Glenn Sipes
  • George F. Kalf
  • David J. Jollow
  • Helmut Greim
  • Terrence J. Monks
  • Charlotte M. Witmer
Series Title
Advances in Experimental Medicine and Biology
Series Volume
387
Copyright
1996
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4757-9480-9
DOI
10.1007/978-1-4757-9480-9
Hardcover ISBN
978-0-306-45197-3
Softcover ISBN
978-1-4757-9482-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIV, 462
Topics