Mechanisms of Lymphocyte Activation and Immune Regulation V

1. Front Matter

   Pages i-ix

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2. Signaling by Antigen Receptors of B Cells

   1. Signaling and Internalisation Function of the B Cell Antigen Receptor Complex

      • Heinrich Flaswinkel, Peter Weiser, Kwang-Myong Kim, Michael Reth

      Pages 1-8

   2. Mechanism of B Cell Antigen Receptor Function: Transmembrane Signaling and Triggering of Apoptosis

      • Anthony L. DeFranco, Paul R. Mittelstadt, Jonathan H. Blum, Tracy L. Stevens, Debbie A. Law, Vivien W.-F. Chan et al.

      Pages 9-22

   3. B-Cell Activation by Wild Type and Mutant Ig-β Cytoplasmic Domains

      • John A. Taddie, Tamara R. Hurley, Bartholomew M. Sefton

      Pages 23-34

   4. Accessory Molecules that Influence Signaling Through B Lymphocyte Antigen Receptors

      • Edward A. Clark, Ingolf Berberich, Stephen J. Klaus, Che-Leung Law, Svetlana P. Sidorenko

      Pages 35-43

3. Signaling by Antigen Receptors of T Cells

   1. Analysis of the (YXXL/I)2 Signalling Motifs Found in the Cytoplasmic Segment of the Mouse CD3-ζ Chain

      • Anne-Marie K. Wegener, Bernard Malissen

      Pages 45-51

   2. Molecular and Genetic Insights Into T Cell Antigen Receptor Signal Transduction

      • Arthur Weiss, Makio Iwashima, Bryan Irving, Nicolai S. C. van Oers, Theresa A. Kadlecek, David Straus et al.

      Pages 53-62

   3. Signal Transduction During T Cell Development

      • Dan R. Littman, Craig B. Davis, Nigel Killeen, Hua Xu

      Pages 63-71

   4. The Regulation and Function of p21Ras in Signal Transduction by the T Cell Antigen Receptor

      • Doreen Cantrell, M. Izquierdo Pastor, M. Woodrow

      Pages 73-79

   5. Immunological Tolerance by Antigen-Induced Apoptosis of Mature T Lymphocytes

      • Lixin Zheng, Stefen A. Boehme, Jeffrey M. Critchfield, Juan Carlos Zuniga-Pflucker, Matthew Freedman, Michael J. Lenardo

      Pages 81-89

4. Signaling Components of Lymphocytes

   1. Properties of Ca Currents Activated by T Cell Receptor Signaling

      • Brett A. Premack, Phyllis Gardner

      Pages 91-102

   2. The Role of Syk in Cell Signaling

      • Robert L. Geahlen, Debra L. Burg

      Pages 103-109

   3. Nonreceptor Tyrosine Kinases in Aggregation-Mediated Cell Activation

      • Brian Seed, Waldemar Kolanus, Charles Romeo, Ramnik Xavier

      Pages 111-119

   4. Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinases

      • Roger M. Perlmutter, Steven J. Anderson

      Pages 121-130

   5. Involvement of Nonreceptor Protein Tyrosine Kinases in Multichain Immune Recognition Receptor Signal Transduction

      • Anne L. Burkhardt, Sandra J. Saouaf, Sandeep Mahajan, Joseph B. Bolen

      Pages 131-141

   6. Phorbol Myristate Acetate-Induced Changes in Protein Kinase C Isozymes (α, β, γ and ζ) in Human T Cell Subsets

      • Sudhir Gupta, William Harris

      Pages 143-148

   7. Specific CD45 Isoforms Regulate T Cell Ontogeny and Are Functionally Distinct in Modifying Immune Activation

      • Jamey D. Marth, Christopher J. Ong, Daniel Chui

      Pages 149-166

   8. Cloning and Characterization of NF-ATc and NF-ATp: The Cytoplasmic Components of NF-AT

      • Steffan Ho, Luika Timmerman, Jeffrey Northrop, Gerald R. Crabtree

      Pages 167-173

5. Signaling VIA Fc Receptors and Cytokine Receptors

   1. Quantitative Aspects of Receptor Aggregation

      • Henry Metzger, Byron Goldstein, Ute Kent, Su-Yau Mao, Clara Pribluda, Victor Pribluda et al.

      Pages 175-183

   2. Fc Receptor Signaling

      • David Brooks, Jeffrey V. Ravetch

      Pages 185-195

Signaling through antigen receptor initiates a complex series of events resulting in the activation of genes that regulate the development, proliferation and differentiation of lymphocytes. During the past few years, rapid progress has been made in understanding the molecular basis of signaling pathways mediated by antigen and cytokine receptors. These pathways involve protein tyrosine kinases which are coupled to downstream regulatory molecules, including small guanine nucleotide binding proteins (e. g. p21'OS), serine threonine kinases (e. g. , members of the ERK family), and a large group of transcription factors. More recently, there have been breakthroughs in elucidating the genetic defects underlying three X-linked primary immunodeficiency diseases in humans. This volume surveys aspects of these rapidly developing areas of research. The book is divided into 5 different sections. Section I deals with signaling pathways in B lymphocytes. It includes a contemporary assessment of B cell antigen receptor structures, and discussion of the role of Ig-a/lg-B polypeptides in linking the antigen receptor to intracellular signal transduction pathways. The role of accessory molecules in the regulation of signaling by the B cell antigen receptor is also considered. Section II adopts a similar approach to the analysis of the antigen receptor on T lymphocytes. The importance of specialized signaling motifs in the CD3 polypeptides, mechanisms whereby these motifs may interact with the lymphocyte-specific protein tyrosine kinases, and the downstream consequences of these interactions are reviewed. In addition, the role of antigen-induced apoptosis in the generation of immunological tolerance is discussed.

• Antigen
• T cell
• apoptosis
• autoimmunity
• cytokine
• development
• immunodeficiency
• lymphocytes
• physiology

• Department of Medicine, University of California, Irvine, USA

  Sudhir Gupta

• National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

  William E. Paul

• Department of Microbiology and Immunology, University of California, San Francisco, USA

  Anthony DeFranco

• Department of Immunology, University of Washington, Seattle, USA

  Roger M. Perlmutter

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