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Pezcoller Foundation Symposia

Apoptosis

Editors: Mihich, Enrico, Schimke, Robert T. (Eds.)

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About this book

The fifth Annual Pezcoller Symposium entitled, Apoptosis, was held in Trento, Italy, June 9-1I, 1993 and was focused on the specific phenomena leading to Programmed Cell Death (PCD) or Apoptosis, and the mechanisms involved. With presentations at the cutting edge of progress and stimulating discussions, this Symposium addressed the genetics and molecular mechanisms determining PCD and the role of this suicidal process in cancer and the immune system. The functions of pS3, c myc and bel 2 in affecting apoptosis in different cell types and the role of ions and intracellular pH changes and that of intranuelear endonueleases are given particular emphasis as are the effects of anticancer agents, hormone imbalances and growth factors. The role of pS3, a tumor suppressor gene, in inducing PCD is discussed in detail as pertinent to hematological and non-hernatological tumors. The requirement of pS3 for the induction ofapoptosis by ionizing radiation or adenovirus oncoproteins is outlined. Decision points during the cell cyele affecting the cascade ofevents leading to PCD are discussed as is their role as "switches" under the control of c-myc and bel-2 proteins or the influence of cyele specific drugs. The concurrent requirement of multiple signals in determining apoptosis is emphasized. The examples of the role of PCD in the regulation of hematopoiesis, and in the generation of antigen-specific immune repertoire are illustrated.

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis Elegans

    Pages 1-13

    Horvitz, H. Robert

  • Apoptosis in Inherited Retinal Degenerations

    Pages 15-29

    Papermaster, David S. (et al.)

  • Wild Type p53 Activity Contributes to Dependence on Hematopoietic Survival Factors

    Pages 31-45

    Gottlieb, Eyal (et al.)

  • Regulation of Apoptosis by the Transforming Gene Products of Adenovirus

    Pages 47-62

    White, Eileen (et al.)

  • C-MYC: Oncogene and Tumour Suppressor Gene

    Pages 63-84

    Evan, Gerard (et al.)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-1-4757-9217-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-0-306-44733-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.99
price for USA in USD
  • ISBN 978-1-4757-9219-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Apoptosis
Editors
  • Enrico Mihich
  • Robert T. Schimke
Series Title
Pezcoller Foundation Symposia
Series Volume
5
Copyright
1994
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4757-9217-1
DOI
10.1007/978-1-4757-9217-1
Hardcover ISBN
978-0-306-44733-4
Softcover ISBN
978-1-4757-9219-5
Edition Number
1
Number of Pages
X, 272
Topics